HIV-free not all it’s made out to be
Many children born virus-free but exposed to it still die earlier than others and may have health issues later in life
Healthy babies born to HIV-positive mums have lower life expectancies
One of the most remarkable public health successes of the last decade in southern Africa has been the reduction in the number of babies born with HIV. This was achieved through the provision of antiretroviral therapy to pregnant and breastfeeding women living with HIV. For example, the number of new HIV infections in children in South Africa has come down from a peak of 70,000 in 2003 to 13,000 in 2017.
Nevertheless, worldwide there are still an estimated 14.8 million children under the age of 15 who were born HIV uninfected but have been exposed to their mother’s HIV during pregnancy.
The largest number of HIV-exposed but uninfected children, 3.2 million, are in SA.
A staggering 30% of pregnant women in South Africa have HIV. Their infants are exposed to both HIV and antiretroviral drugs during pregnancy and breastfeeding. HIVexposed but uninfected children don’t have HIV, so what’s the big deal?
It is a big deal because HIV-uninfected children born to mothers with HIV are prone to infections that are more severe, are at almost two times greater risk of dying before their first birthday, and are more likely to be born prematurely than children born to mothers without HIV.
In our recent study we set out to try and quantify the contribution of deaths in HIVexposed but uninfected infants to the overall infant mortality rates in Botswana and South Africa.
What we found was that because children born to mothers with HIV make up almost one in every four infants in Botswana and South Africa, and because they die more often than children born to mothers without HIV – even when they are HIV-uninfected themselves – this contributed to a higher infant mortality rate in both countries.
Even when they’re not HIV infected, children born to women with HIV experience a complex package of detrimental exposures.
For example, HIV-exposed but uninfected infants are still more often born preterm or of low birth weight. This increases their risk for complications and death early in life.
They are also exposed to more infectious pathogens in the home such as tuberculosis.
There are other problems too. Breastfeeding has enormous nutritional and immunological benefits. Maternal access to antiretrovirals has made it safer but sustained breastfeeding is still low. One study in South Africa showed that, irrespective of HIVstatus, women stopped breastfeeding their babies on average when the infants were eight weeks old.
On top of this, HIV-exposed infants more often have mothers who are unwell or who have died. And HIV-affected households experience challenging socioeconomic circumstances that can make children more vulnerable. These exposures in the first 1,000 days of life can be detrimental to early childhood development and have lifelong consequences.
In addition, infants born to women with HIV are subject to factors during pregnancy that unexposed infants aren’t. These include exposure to HIV particles, that may make their immune systems develop differently. And these infants are exposed to at least three antiretroviral drugs given to the mother during pregnancy.
To estimate the contribution of deaths in HIV-exposed but uninfected infants to the overall infant mortality rates we used previously published research comparing the mortality risk in HIV-exposed uninfected infants to risk of mortality in unexposed infants, as well as United Nations estimates of infant mortality in Botswana and South Africa.
In Botswana, HIV exposed uninfected infants accounted for 26% of the infant population but 42% of all infant deaths. Similarly, in South Africa HIV exposed uninfected infants accounted for 23% of the infant population but 38% of all infant deaths.
Putting this into actual numbers, this extra mortality in HIV-exposed uninfected infants increased the overall HIV-uninfected infant mortality rate in both Botswana and South Africa from around 30 deaths per 1,000 infants to 35 deaths per 1,000 in 2013.
Botswana and South Africa have adopted the World Health Organisation’s recommendation to provide lifelong antiretrovirals to all pregnant and breastfeeding women with HIV. But there’s a lack of research comparing the mortality of HIV-exposed to unexposed infants under these new guidelines.
Our calculations are therefore based on the year 2013, the most recent year before policy shifts in both countries. There is emerging evidence though of a persisting increase in mortality in HIV-exposed infants even with maternal antiretroviral therapy.
With one in every four children in Botswana and South Africa being HIV and ARVexposed, robust systems need to be put in place to monitor the long-term safety of these exposures during pregnancy. Countries need to invest in research to understand why HIVexposed children still have an increased risk of dying. – The Conversation
Amy Slogrove is senior lecturer in paediatrics and child health at Stellenbosch University, Kathleen M Powis is assistant professor at Harvard Medical School and Mary-Ann Davies is associate professor and director of the Centre for Infectious Diseases Epidemiology and Research at the University of Cape Town.
Countries need to research to understand why HIV-exposed children still have an increased risk of dying