Pill for bone cancer shows positive results for baldness
SCIENTISTS could be close to discovering one of the holy grails of medicine – the cure for baldness.
A pill taken twice a day has been shown to restore hair growth for men and women within just four months.
The results from a drug used to treat bone marrow cancer will bring hope to millions whose hair is thinning.
The improvement was seen in people with alopecia, but US researchers said lab results suggest it could also help with common types of baldness.
Millions of men have male-pattern baldness, the natural loss of hair from the temples and crown, with some starting to go bald in their teens. Millions of women also have thinning hair, and experts say they are more likely to be psychologically affected.
But a drug called ruxolitinib given to people with alopecia areata, which makes hair fall out in clumps, appears to reverse the process.
Although some patients affected recover within the first year, others will progress to lose all their bodily hair.
Ruxolitinib is used to treat cancer of the bone marrow, but when given to the alopecia sufferers, it had a dramatic effect.
Nine of 12 men and women involved in the US trial grew at least half their hair back – and some regained more than 95 percent.
A few suffered side-effects, including acne and allergies, but these were minor and short-lived.
However, the Journal of Clinical Investigation reports that hair began to fall out again for several patients after the treatment was stopped.
It is thought ruxolitinib, part of a family of drugs known as JAK inhibitors, worked its magic by stopping the immune system from attacking the cells that sprout hair.
Angela Christiano, of the Columbia University Medical Centre in New York, said: “The results have been quite astounding compared with previously available treatments.”
With a similar drug that also tricks hair into regrowing being tested at Stanford and Yale universities in the US, hopes of a treatment for alopecia are high. To the surprise of Columbia University researchers, experiments on mice suggest that ruxolitinib might also help with male-pattern baldness, even though the condition is quite different to alopecia.
More research into the drug is under way, but if larger and longer trials show it is safe and effective, it could be widely used to treat alopecia within five years.
Last year, scientists in Japan found that a waxy material called propolis, used by bees to seal small gaps in their hives, stimulated hair growth.
The effects were studied on mice, but the scientists believe they have relevance to millions of people whose hair is thinning.
Propolis is a natural antiseptic and has been used for thousands of years as a treatment for everything from cancer to cold sores.
The team, from Hokkaido University in Sapporo, applied the substance to the backs of mice that had been shaved or waxed.
Those given the treatment regrew their fur faster than others. After three weeks, the treated mice still had all their fur, while the other animals only had patchy regrowth.–