Antihistamines linked to fertility problems in men
Common allergy drugs have been linked to fertility problems in men. Antihistamines are often used to relieve symptoms of allergies and reactions to insect bites or stings and are available over-the-counter.
Now an Argentinian review of studies involving the commonly taken drugs has found that they could have negative long-term side effects for male fertility. The study, which is published in the journal Reproduction, found a number of papers reported adverse effects of antihistamine on normal testicular function. They discovered antihistamines were likely to affect the production of male sexual hormones in the testicles, which could lead to altered morphology and decreased motility of sperm, as well as a lower sperm count. The researchers, who analysed a number of animal studies, said further research was needed as human studies were still limited, but they cautioned against antihistamine overuse. The rise in allergies in the industrialised world has led to an increased use of drugs such as antihistamines.
Histamine is a molecule produced by the body in response to an allergy that makes the sufferer react to it, such as by sneezing or itching, and previous research has shown that histamines are also involved in other bodily processes unrelated to allergic reactions, including sleep-wake regulation, sexual behaviour and fertility. Researchers at the Instituto de Biologia y Medicina Experimental in Buenos Aires said this suggested that blocking histamine activity to treat allergy symptoms may lead to undesirable side effects. Commenting on the research, Dr Channa Jayasena, senior clinical lecturer at Imperial College London, said: “The average sperm quality in the population has been reducing over the last few decades, so it is always important to consider that common (and increasingly used) medications may be partly responsible. The authors aim to summarise previous scientific studies in the field. As they rightly acknowledge, it is too soon to raise alarm bells about taking these medications. Many agents have been linked to male infertility. The trick is working out how much overall impact they have on men’s reproductive health.” (Courtesy The Guardian, UK)