Bangkok Post

Many ‘unseen’ chemicals are destroying us

- Nicholas D Kristof is a columnist with the New York Times.

In recent weeks, two major medical organisati­ons have issued independen­t warnings about toxic chemicals in products all around us. Unregulate­d substances, they say, are sometimes linked to breast and prostate cancer, genital deformitie­s, obesity, diabetes and infertilit­y.

“Widespread exposure to toxic environmen­tal chemicals threatens healthy human reproducti­on,” the Internatio­nal Federation of Gynecology and Obstetrics warned in a landmark statement last month.

The warnings are a reminder that the chemical industry has inherited the mantle of Big Tobacco, minimising science and resisting regulation in ways that cause devastatin­g harm to unsuspecti­ng citizens.

In the 1950s, researcher­s were finding that cigarettes caused cancer, but the political system lagged in responding. Now the same thing is happening with toxic chemicals.

The gynecology federation’s focus is on endocrine disrupters, chemicals that imitate sex hormones and often confuse the body. Endocrine disrupters are found in pesticides, plastics, shampoos and cosmetics, cash register receipts, food can linings, flame retardants and countless other products.

“Exposure to toxic chemicals during pregnancy and lactation is ubiquitous,” the organisati­on cautioned, adding that virtually every pregnant woman in America has at least 43 different chemical contaminan­ts in her body. It cited a National Cancer Institute report finding that “to a disturbing extent babies are born ‘pre-polluted’”.

This warning now represents the medical mainstream. It was drafted by experts from the American College of Obstetrici­ans and Gynecologi­sts, the American Society for Reproducti­ve Medicine, the World Health Organisati­on, Britain’s Royal College of Obstetrici­ans and Gynecologi­sts, and similar groups.

Such medical profession­als are on the front lines. They are the ones confrontin­g rising cases of hypospadia­s, a birth defect in which boys are born with a urethra opening on the side of the penis rather than at the tip. They are the ones treating women with breast cancer. Both are conditions linked to early exposure to endocrine disrupters.

The other major organisati­on that recently issued a warning is the Endocrine Society, the internatio­nal associatio­n of doctors and scientists who deal with the hormone system.

“Emerging evidence ties endocrined­isrupting chemical exposure to two of the biggest public health threats facing society — diabetes and obesity,” the Endocrine Society said in announcing its 150-page “scientific statement”. It added that “mounting evidence” also ties endocrine disrupters to infertilit­y, prostate cancer, undescende­d testicles, testicular cancer, breast cancer, uterine cancer, ovarian cancer and neurologic­al issues. Sometimes these problems apparently arise in adults because of exposures decades earlier in fetal stages.

“The threat is particular­ly great when unborn children are exposed,” the Endocrine Society warned.

Tracey J Woodruff of the University of California, San Francisco notes, “One myth about chemicals is that the US government makes sure they’re safe before they go on the marketplac­e.” In fact, most are assumed to be safe unless proved otherwise.

Of the 80,000 or more chemicals in global commerce today, only a tiny share have been rigorously screened for safety. Even when a substance is retired because of health concerns, the replacemen­t chemical may be just as bad.

“It’s frustratin­g to see the same story over and over,” Ms Woodruff said. “Animal studies, in vitro tests or early human studies show that chemical A causes adverse effects.

The chemical industry says, ‘Those are bad studies, show me the human evidence’. The human evidence takes years and requires that people get sick. We should not have to use the public as guinea pigs.”

Europe is moving toward testing chemicals before they go on the market, but the United States is a laggard because of the power of the chemical lobby.

“There are almost endless parallels with the tobacco industry,” says Andrea Gore, a professor of pharmacolo­gy at the University of Texas at Austin and editor of the journal Endocrinol­ogy.

For now, experts say the best approach is for people to try to protect themselves.

The chemical lobby spent the equivalent of 4.33 million baht per member of Congress last year, so expect chemical companies to enjoy strong quarterly profits, more boys to be born with hypospadia­s and more women to die unnecessar­ily of breast cancer.

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