BP medicines don’t raise Covid-19 risk: Latest research

washington — Commonly used blood pressure medicines do not heighten susceptibility to Covid-19 infection, or increase the risk of becoming seriously ill with the disease, three major studies said, positive news for the millions of people who take them.

The research primarily concerned angiotensin-converting-enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs), which are also given to diabetes patients to help protect their kidneys.

ACE inhibitors include the likes of ramipril, lisinopril and other drugs ending in -pril; while ARBs include valsartan and losartan, and generally end in -sartan.

There had been concern arising from animal studies that these medicines might increase the body’s levels of a protein called ACE2, which the coronavirus latches on to when it invades human cells, thus increasing people’s vulnerability to the disease.

Confusing matters further, there were also contradictory animal studies that showed having more ACE2 proteins might lessen an inflammatory reaction in lungs to Covid-19, a beneficial effect.

The three new studies were published in the New England Journal of

Medicine (NEJM).

Each involved reviewing the records of thousands of people either on or not on the medicines and seeing if they got infected and how the disease progressed.

They then used statistical methods to control for other factors like underlying health conditions that might make people more susceptible to infection and to serious Covid-19.

“We saw no difference in the likelihood of a positive test with ACE inhibitors and with angiotensin receptor blockers,” Harmony Reynolds of the NYU Grossman School of Medicine, who led one of the studies that involved about 12,600 people, said.

The studies were “observational,” meaning the researchers observed the effect of a risk factor.

This type of investigation is always considered weaker than “experimental” where an intervention is introduced along with a control, which leaves less to chance.

The authors of an accompanying editorial in the NEJM acknowledged this inherent limitation, but added: “We find it reassuring that three studies in different populations and with different designs arrive at the consistent message.” —

I’m very happy to be able to tell patients that they should continue their blood pressure medications Harmony Reynolds

NYU Grossman School of Medicine