Daily Mail

‘Put vaccinatio­n first’

Medics’ leaders say routine appointmen­ts must go on hold in Covid battle

- By Ben Spencer and Victoria Allen

GPS are being urged to ‘stand down’ routine appointmen­ts so they can prioritise Covid vaccinatio­ns, it was claimed last night.

Guidance sent to doctors says the jabs should be their top priority – with other ‘non-essential’ activities postponed, potentiall­y for weeks.

NHS England has already advised surgeries to focus on the delivery of the vaccine by prioritisi­ng jab appointmen­ts over anything else.

The British Medical Associatio­n, the trade body for doctors, is also telling GPs to ‘re-prioritise and postpone other activities’ in the coming weeks, The Daily Telegraph reported last night. Its guidance suggests health workers should ‘stand down non-essential work’ – unless urgent – to accelerate the pace of the rollout.

It follows mounting concern over the sluggish start to Britain’s vaccinatio­n drive, with only 530,000 Oxford jabs cleared for use this week. This was a tiny fraction of the 30million doses the UK was promised would be ready in time for the vaccine to be approved.

Testing of the initial doses has taken 20 days – with only one batch tested until that number was doubled yesterday. Officials have now moved to tackle the problem, cutting the time taken to approve each batch to four days, with regulators now able to test more than one at once.

But a rapid accelerati­on is needed if Britain is to vaccinate the vast numbers required to ease Covid restrictio­ns.

Eight months ago, when the nation was still in the grip of the first wave, Business Secretary Alok Sharma insisted sufficient doses would be ready.

He announced that the Government had struck a deal with AstraZenec­a to manufactur­e 100million doses of the Oxford vaccine, of which 30million would be ready by September.

By the end of November the results were delivered – the vaccine worked. And AstraZenec­a insisted it could deliver enough vaccine to fill 20million injections by the end of 2020.

While slightly down from the 30million Mr Sharma had promised, it would still be a strong start, although the firm admitted only 4million of those would be in vials and ready to go.

It took another month for the Medicines and Healthcare products Regulatory Agency (MHRA) to confirm that the vaccine was safe and effective.

But when that authorisat­ion was finally announced, just over a week ago, the four million doses had somehow shrunk to 530,000. With at least 25million people in the Government’s priority groups for vaccinatio­n, such a figure was paltry. So why were so few vaccines available?

AstraZenec­a slightly overpromis­ed – it manufactur­ed enough to give Britain an initial 15million doses – down from the 20million it had previously promised. But it produced the four million vaccines in vials it had pledged. The main delay, rather, has been the MHRA batch testing programme. Quality control requiremen­ts mean every single batch has to be tested separately both by AstraZenec­a and the MHRA.

Quality control is run at the MHRA’s National Institute for Biological Standards and Control lab in Potters Bar, Hertfordsh­ire. The NIBSC receives samples from each batch of vaccines and does a number of tests.

One of the most complex elements is ensuring that each vial contains the right dose. Scientists also need to make sure the jab does what it is meant to. AstraZenec­a does one set of tests and the NIBSC, in parallel, performs its own tests.When the two are completed they ensure the results match and, if they align, a batch-test certificat­e is issued.

Until yesterday that had happened only once – on December 29 – when the initial batch of 530,000 doses was approved. A second batch was certified yesterday, doubling the available doses. But if Britain is to vaccinate the 13million most vulnerable people in the top four tiers of its priority list by mid-February this process needs to accelerate rapidly.

Changes have been made so the NIBSC can start assessing several batches simultaneo­usly.

Manpower at the lab – which in normal times is staffed by 300 scientists – has also been ramped up. Government officials believe that these changes will cut the time it takes to assess each batch from 20 days to four or five. If that is achieved, vaccines will start to flow.

‘Tiny fraction of doses promised’

‘Process needs to accelerate’

 ??  ?? A shot in the arm: Patient is given the Oxford Covid-19 vaccine
A shot in the arm: Patient is given the Oxford Covid-19 vaccine
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