Be aware of your pills’ ‘inactive’ ingredients
FIRST AID FOR EPILEPTICS
Epilepsy affects 600,000 people in the UK yet research carried out one epilepsy charity showed that two out of three people wouldn’t know how to help someone during a seizure and nor would a quarter of those with a family member with the condition.
The Epilepsy Society’s new campaign gives people three simple but key instructions to remember in an emergency: “Calm, Cushion, Call.” ■ Stay CALM and stay with the person who is having a seizure.
■ CUSHION their head with a coat or cardigan to stop them injuring themselves.
■ CALL 999 if the seizure does not stop.
And here are a few more additional details on what to do:
■ Look around, if there’s no danger don’t move them. Move objects such as furniture away.
■ Note the time the seizure starts.
■ If they don’t collapse but seem blank or confused, gently guide them to safety. Speak quietly and calmly to them.
■ Don’t hold them down and don’t put anything in their mouth.
■ If a seizure doesn’t stop after five minutes, call for an ambulance (dial 999).
■ After the seizure has stopped, gently put them into the recovery position and check their breathing is returning to normal. Check that nothing is blocking their airway such as food or false teeth. If their breathing sounds difficult after the seizure has stopped, call for an ambulance.
■ Stay with them until they’re fully recovered.
Call an ambulance if:
■ it’s their first seizure
■ they’ve injured themselves badly during the seizure
■ they have trouble breathing after the seizure has stopped
■ one seizure immediately follows another with no recovery in between ■ the seizure lasts two minutes longer than is usual for them
■ the seizure lasts for more than five minutes
For more details about the condition, see epilepsysociety.org.uk.
When I was running an allergy clinic, I often had reason to look at so-called inactive ingredients in tablets, capsules, creams and lotions. And even though these ingredients are called inactive, many of them aren’t.
They can trigger allergies. Plus, in any given medicine, they can account for 90% of the contents.
These “inactive” ingredients are called excipients and are there to pack out the active drug. If you think about it, the active drug may only be 50mg but it comes as a tablet weighing 500mg. The difference between the active drug and the labelled weight is the weight of the excipients, 450mg.
If you’re allergic to any of these excipients, that amount could cause a lot of trouble.
A&E records about 1.3 million visits for bad reactions to drugs every year. New research from Massachusetts Institute of Technology suggests many of those reactions might not be to the active drug. All ingredients in a
medicine, active or inactive, have to be disclosed, either on the label, the package or in the package insert.
Inactive ingredients that may not be as immediately obvious as the active ones are mostly things generally regarded as safe – GRAS – by medicine authorities.
Something that’s safe for the vast majority of people, however, could pose serious risks to a small section of the population.
For instance, gluten is used as an excipient. But one in every 100 people in the UK has coeliac disease and can’t eat gluten.
A 2013 study of the top 200 mostprescribed drugs found that the majority had some amount of gluten in them – however small – that could have potentially caused a reaction in a person with coeliac disease.
Senior study author Dr Giovanni Traverso said: “I think there’s a tremendous unappreciation of the potential impact that inactive ingredients may have.”
He and his team set out to try to quantify that impact, poring over earlier studies that mentioned bad drug reactions. They found 93% of medications contained ingredients that could trigger allergic reactions, including dyes, peanut oil, gluten, lactose or sugars. And these supposedly “inactive” ingredients made up more than half (55%) of most drugs, and as much as 99% of some.
Now the researchers hope doctors, patients, drug firms and regulators will be encouraged to disclose ingredients more clearly and even push for alternative formulations of drugs.
“I think all of these really need to come together,” Dr Traverso said.
“Education, increased awareness and legislation are all important.”
The majority of drugs had gluten in them