It’s Channel 4’s big charity telethon night, aiming to bring in cash galore for the country’s cancer research charities.

And they’re certainly putting the fun into fundraising, with a whole host of special programmes, big names popping up in sketches and another unmissable Celebrity Gogglebox.

Presenting events in the studio are comedians Adam Hills and Alan Carr, along with DJ Maya Jama. They’ll be joined by musical guests including John Legend, Liam Gallagher, Little Mix and Louis Tomlinson.

Big highlights are king of the crooners Michael Buble’s Carpool Karaoke special with James Corden, a sketch from Miss Piggy and the Muppets, Celebrity Bake Off stars, and a host of famous faces battling against each other in SU2C challenges.

There’ll be a musical tribute to Aretha Franklin, Davina McCall tasks Made In Chelsea stars Jamie and Spencer with creating a charity single, princesses Beatrice and Eugenie demonstrate their interviewing expertise, and Noel Fielding and Richard Ayoade show off their boffin skills by explaining the science behind some of the pioneering research that SU2C funds.

Have the tissues at hand for the array of emotional appeal films. They’re fronted by actors Eddie Redmayne, Benedict Cumberbatch, Tom Hardy, Liam Neeson and Jodie Comer, plus Match of the Day host Gary Lineker.

Sharon Horgan will join forces with Clare Balding, Prue Leith and Katherine Ryan to highlight to women the importance of checking their boobs, while David Mitchell, Jonathan Ross, Bear Grylls and Jack Whitehall talk tackle to the men.

The Last Leg boys will be joined by a load of comedians for the final fling in the studio and a lead-up to the unveiling of the grand total.

Watch, listen, laugh, cry and enjoy – and donate.