Alzheimer’s genes ‘breakthrough’

SCIENTISTS have discovered nearly 150 genes linked to thinking skills in a breakthrough that could help combat Alzheimer’s disease.

A team led by the University of Edinburgh found 148 genes that could have an impact on thinking skills – such as memory, reasoning, speed of mental processing and spatial awareness.

Scientists said the results could help understanding of the declines in cognitive function that happen with illness and as people age.

The study analysed data from 300,486 people aged between 16 and 102 who had taken part in 57 cohort studies in Australia, Europe and North America.

Dr Gail Davies, of the University of Edinburgh’s Centre for Cognitive Ageing and Cognitive Epidemiology, who led the analysis, said: ‘This study, the largest genetic study of cognitive function, has identified many genetic differences that contribute to the heritability of thinking skills.

‘The discovery of shared genetic effects on health outcomes and brain structure provides a foundation for exploring the mechanisms by which these differences influence thinking skills throughout a lifetime.’

As well as having better thinking skills, the genetic areas are associated with better cardiovascular and mental health, lower risk of lung cancer and longer life.

Those who participated in the study, published in Nature Communications, had taken a variety of thinking tests which were summarised as a general cognitive ability score.

All had genetic testing that examined their DNA and none had dementia or a stroke.