Scottish Daily Mail

Did the horror of Spanish flu fool us we had IMMUNITY from corona

Millions dead. Families left in penury. And so catastroph­ic we told ourselves it could never happen again. So ...

- by Laura Spinney LaURa spINNEY is the author of pale Rider: the spanish Flu Of 1918 and How It Changed the World. this is adapted from an article that appeared in the Guardian. © Guardian News & Media Ltd 2020.

PlAGUES — or, to use a more modern term, epidemics of infectious disease — pluck at our most primal fears. We have lived with them for at least 10,000 years, ever since our ancestors took up farming and built the first semi-permanent settlement­s. And they have always had the upper hand.

They know us intimately, preying on our strengths — our sociabilit­y, our love of gossip — and turning them into weaknesses. They are always a step ahead and, once they are out, like the genie, we can’t get them back in. All we can do is limit the damage. So here we are again.

Epidemics are frightenin­g, so it is hardly surprising that people reach for the worst possible historic comparison.

The 1918 influenza pandemic, which has been distilled in the public imaginatio­n to a single photograph of bedridden U.S. soldiers, has been hauled out of mothballs to do duty as a template of what we might expect from Covid-19.

But is that global human catastroph­e, which killed between 50 million and 100 million people and which was largely forgotten for most of the last century, the right comparison to make?

on Wednesday the World Health organisati­on (WHo) declared the Covid-19 outbreak a pandemic — that is, by the WHo’s own definition, ‘the worldwide spread of a new disease’.

At the time of writing there are more than 125,000 cases in 117 countries and 4,613 people have died.

Prime Minister Boris Johnson on Thursday called it ‘the worst public health crisis in a generation’, and the UK’s Chief Scientific Adviser, Sir Patrick vallance, said that between 5,000 and 10,000 Britons could already be infected, though only 590 of those have been identified by testing to date.

The virus that causes Covid-19, SarsCov-2, is a new pathogen in humans, meaning we are all immunologi­cally naive to it. it is very contagious, but we don’t yet know how lethal it is.

ONE way of measuring this is by the Case Fatality Rate (CFR), the proportion of people who fall sick who go on to die. last week, the WHo provisiona­lly quoted a CFR of 3.4 per cent, which would be alarming if it were correct.

The CFR of the 1918 flu is still being debated, mainly because there was then no reliable diagnostic test for flu, but the number usually quoted is 2.5 per cent.

Regarding Covid-19, data is sketchy for the moment, and everyone agrees it will be a while before we know the real CFR, but there’s already good evidence that many cases are going unreported — in part because those affected have very mild symptoms. That would mean the CFR is lower than 3.4 per cent — perhaps as low as that of severe seasonal flu, which is about 0.1 per cent.

So we could ask why we are comparing this outbreak to the 1918 pandemic, which was such an outlier in terms of the number infected and the fatality rate, and not the two other flu pandemics that struck in the 20th century — the 1957 Asian flu, and the 1968 Hong Kong flu.

Both had CFRs much closer to 0.1 per cent, and neither killed more than three million people at the most.

To bring the picture right up to date, we could include the 2009 H1N1 flu pandemic, which killed in the region of 600,000 people. These are still big numbers, and they dwarf those attributed to Covid-19 to date. But i reiterate: the 1918 flu was in a different ballpark.

Another major difference between the 1918 flu and Covid-19 is that the flu mainly affected those aged between 20 and 40, while Covid-19 mainly affects those over 60.

The British virologist and flu historian Professor John oxford, of Queen Mary University of london, calls Covid-19 ‘a pale reflection of 1918 where 200,000 [Britons] died quietly at home and most of them were young’.

indeed, one of the reasons the 1918 flu was so devastatin­g was because it purged communitie­s of their breadwinne­rs — at a time when there wasn’t much of a social welfare safety net to catch those left behind. Should we be comparing Covid-19 to flu at all?

The viruses that cause the two diseases belong to different families. Sars-Cov-2 belongs to the coronaviru­s family, other members of which caused the outbreak of severe acute respirator­y syndrome (Sars) in China between 2002 and 2004, and of Middle East respirator­y syndrome (Mers), which began in Saudi Arabia in 2012.

Sars and Mers were far more lethal than Covid-19, boasting CFRs of 10 per cent and 36 per cent respective­ly, but the viruses that cause all three seem to spread in a similar way.

Unlike flu, which spreads rapidly and relatively evenly through a population, coronaviru­ses tend to infect in clusters. in theory, that makes coronaviru­s outbreaks easier to contain, and, indeed, both Sars and Mers outbreaks were brought under control before they went global.

Annelies Wilder-Smith, a professor of emerging infectious diseases at the london School of Hygiene and Tropical Medicine, thinks that the unwarrante­d comparison­s with flu may have prevented many Western government­s from taking the rigorous action that was needed to contain Covid-19 now, while it was still possible.

‘The short-term costs of containmen­t look high,’ she says, ‘But they’re much lower than the long-term costs of non-containmen­t.’

Wilder-Smith is not alone in having shifted her opinion in

recent weeks towards the idea that Covid-19 may be the ‘big one’ that infectious disease experts have been fearing.

When such experts say ‘big one’, they mean a pandemic, but it’s not clear how big they mean, because they don’t want to put numbers on it.

That’s understand­able, if they think that much depends on what we do, or don’t do, next.

Mathematic­al modellers, whose job it is to put numbers on things, have estimated that up to 80 per cent of Britons could be infected, and 500,000 could die (out of a far bigger UK population than in 1918), before this outbreak recedes.

But that is very much a worstcase scenario and one that assumes that containmen­t and delay have no impact.

The bottom line, then, is that Covid-19 will almost certainly not turn out to be as bad as the 1918 flu pandemic, but it could still be bad, perhaps on a par with the pandemics of 1957 or 1968.

Until a vaccine becomes available — which isn’t likely for at least 18 months — our best hope for minimising levels of sickness and death is now to slow the disease’s spread.

THAT means the rigorous implementa­tion of ‘social distancing’ — the collective term for measures that keep the sick and the healthy apart, and so reduce disease transmissi­on.

And where social distancing is concerned, historical comparison­s can help, because the techniques — quarantine, isolation, masks and handwashin­g, among them — don’t change.

one lesson government­s took from 1918 is that mandatory public health measures tend to be counterpro­ductive.

Containmen­t is much more effective if people choose to comply. But for that to happen, they need to be properly informed about the threat, and to trust the authoritie­s to act in their collective interest.

If either, or both, of these things is missing, containmen­t works less than well. In 1918, most government­s were caught unawares by the pandemic and public informatio­n campaigns were risible.

one of the reasons the 1918 flu came to be known as the Spanish flu was because Spain was neutral in the war and didn’t censor its press. Whereas the U.S., Britain and France — all of which had the flu before Spain — kept it out of the newspapers at first, to avoid damaging morale.

When they finally acknowledg­ed it, the newspapers issued conflictin­g public health messages and repeated unfounded rumours — including one that german U-boats beaching in the U.S. had deliberate­ly sown the flu.

germ theory — according to which infectious diseases are caused by microscopi­c organisms — was also relatively new. Inevitably, people found it easy to revert to more mystical explanatio­ns of what was happening.

In the deeply pious Spanish city of Zamora, for example, the bishop defied the authoritie­s by ordering a novena — evening prayers on nine consecutiv­e days — in honour of Saint rocco, the patron saint of plague and pestilence.

This involved churchgoer­s lining up to kiss the saint’s relics, around the time that the outbreak peaked. Zamora went on to record the highest flu-related death rate of any city in Spain, and one of the highest in europe.

New York City, on the other hand, experience­d one of the lowest death rates. The city’s inhabitant­s were used to public health interventi­ons by 1918, since local authoritie­s had orchestrat­ed a 20-year campaign against tuberculos­is.

But some New Yorkers had other ideas: local papers reported on a ‘black wedding’ in Mount Hebron cemetery, where two Jewish strangers were married in an ancient ritual to ward off plague.

Meanwhile, in the business community, there was resistance to restrict attendance at places of entertainm­ent.

When Charlie Chaplin’s film Shoulder Arms was released in the autumn of 1918, Harold edel, the manager of the Strand Theatre — a cinema on Times Square — praised his customers for their turnout. He died of flu a few weeks later.

The world of 2020 is vastly different from that of 1918. Howard Phillips, a historian of the 1918 flu

Victims: Soldiers lie in bed during the 1918 flu epidemic at the University of Cape Town in South Africa, observes ‘the relative silence of organised religion’ during this outbreak, compared with the 1918 pandemic.

Laura Jambrina, a teacher in Zamora, notes that today the church authoritie­s have been more vocal in their guidance than the secular, provincial ones, advising worshipper­s to wash their hands and not to sprinkle holy water.

religion has, neverthele­ss, played a part. The South Korean cluster of Covid-19 seems to have spread via churches, while pilgrims in Iran have posted videos of themselves defiantly licking the Fatima Masumeh shrine in the city of Qom.

Many other things haven’t changed. There was a lot of fake news in 1918 and there’s a lot of fake news now, and in 2020, its volume and speed of transmissi­on is unpreceden­ted. Donald Trump’s grandfathe­r died of the 1918 flu, yet the U.S. President has been accused of misleading Americans over the Covid-19 outbreak through his tweets.

Meanwhile, hashtags circulatin­g on Italian social media — such as #FlorenceDo­esntStop, #CultureAga­instFear — could partly explain the difficulty the Italian authoritie­s initially had in containing the outbreak — and why they are now in the ‘mitigate’ phase.

AProMINeNT Italian politician, Nicola Zingaretti, announced last weekend that he had come down with Covid-19 after organising a party on the theme of #MilanDoesn­tStop. The Harold edel of our day will hopefully make a speedy recovery.

There have been horrifying reports of people drinking industrial alcohol or taking cocaine to ward off Covid-19. In 1918, too, people thought alcohol would protect them, and quacks cashed in on ‘elixirs’ for which they charged exorbitant prices.

And we seem to have forgotten that closing borders against infectious disease doesn’t work. Many countries have done so, despite the WHo’s advice, but they are now discoverin­g that the virus is already on the inside — and they have still got to deal with it.

The U.S. is among them, and still President Trump suspended travel from europe to the U.S. this week.

It’s a lesson we seem to have to learn again every time a new pandemic appears, and the kneejerk tendency to pull up the drawbridge shares xenophobic roots with blaming ‘the other’.

In 1918, before the name ‘Spanish flu’ caught on, Brazilians called it the german flu, while the Senegalese called it the Brazilian flu. The Poles called it the Bolshevik disease and the Danes thought it ‘came from the south’. Now Chinese people are getting the blame.

If there is one feature of the current epidemic for which we should applaud ourselves, it is that we have managed to avoid giving this outbreak a stigmatisi­ng name. The WHo guidelines of 2015 on how to name diseases can take a lot of credit for this.

So this new plague is not the Chinese flu or the Pangolin flu, a reference to the scaly mammal in which this coronaviru­s was initially thought to have originated, but the rather more mundane Covid-19. Just one more epidemic in a long line of epidemics that have struck fear into our hearts, and that we can still rein in if we would just listen to our brains instead.

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Picture:MARYEVANS/MEDIADRUMI­MAGES

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