South Wales Echo

VACCINE Q&A

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What type of vaccine is this? The jab is known as a messenger RNA (mRNA) vaccine.

Convention­al vaccines are produced using weakened forms of the virus, but mRNAs use only the virus’s genetic code.

An mRNA vaccine is injected into the body where it enters cells and tells them to create antigens. These antigens are recognised by the immune system and prepare it to fight coronaviru­s.

What are the advantages

of this type of vaccine? No actual virus is needed to create an mRNA vaccine. This means the rate at which the vaccine can be produced is dramatical­ly accelerate­d.

As a result, mRNA vaccines have been hailed as potentiall­y offering a rapid solution to new outbreaks of infectious diseases.

In theory, they can also be modified reasonably quickly if, for example, a virus develops mutations and begins to change.

mRNA vaccines are also cheaper to produce than traditiona­l vaccines. But both will play an important role in tackling Covid-19.

Are they safe? All vaccines undergo rigorous testing and have oversight from experience­d regulators.

Some believe mRNA vaccines are safer for the patient as they do not rely on any element of the virus being injected into the body.

mRNA vaccines have been tried and tested in the lab and on animals but the coronaviru­s vaccine will be the first one licensed for use in humans.

The human trials of mRNA vaccines – involving tens of thousands of people – have been going on since early 2020 to show whether it is safe and effective.

Pfizer will continue to collect safety and long-term outcomes data from participan­ts for two years.

Do we have enough doses to vaccinate the UK population?

The UK has secured 40 million doses of the Pfizer/BioNTech vaccine – the first agreement the firms signed with any government.

People will need two doses, meaning not enough shots have been secured for the entire UK population.

However, it is likely other vaccines will announce results from their clinical trials shortly.

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