South Wales Echo

How likely is

- WILL HAYWARD Welsh affairs editor will.hayward@walesonlin­e.co.uk

WILL Wales be going into another lockdown? That is the question that is on many people’s minds.

The average rate of Covid infections in Wales has now reached 716.9 per 100,000 people – the highest since the pandemic began.

Blaenau Gwent has a case rate of 1,185, which makes it the area of the UK with the highest infection rate.

In the second week of August, Wales lifted restrictio­ns. Fast-forward 10 weeks and there are very real concerns about whether we could be facing another lockdown this winter.

But how likely is a lockdown? Across the border, Prime Minister Boris Johnston has so far defiantly ruled it out.

To answer this question, we spoke to three Covid experts – Martin Michaelis, a professor of molecular medicine at the University of Kent; Dr Simon Williams, a behavioral scientist and a senior lecturer in people and organisati­on at Swansea University; and Mike Gravenor, a professor of epidemiolo­gy at the Swansea University Medical School and part of the team who produces the modelling used to inform Welsh Government decision-making.

Ultimately, the decision of whether or not to go into a lockdown will be taken by the First Minister Mark Drakeford.

He has indicated that he will only ever do this if it is needed to protect the NHS.

Whether this happens or not will depend on several factors which are hard to predict – the virus has been full of unforeseea­ble twists and turns – but given the interest in the issue, it is worth digging into the data to see what cautious prediction­s we can make.

Both Prof Michaelis and Dr Williams are sceptical about the need for further lockdowns.

Dr Williams said: “Lockdowns are a thing of the past.

“We won’t see anything like what we had last year – where we had a stay-at-home order. I suspect the Covid Pass may be extended into new venues – perhaps bars, restaurant­s etc, like in Denmark – at least that is the next step into the plan.

“Beyond that, if things really get bad, then we may see some of the Alert Level One measures come back, where there are limits imposed on the numbers of people being able to mix indoors and where social distancing is reintroduc­ed.

“Hopefully, it won’t come to this, but that is why minimising our mixing voluntaril­y and trying to keep wearing our masks where required is important. But, also, the government and employers need to support people to work from home and to self-isolate where needed.”

He added: “The days of lockdowns are thankfully behind us. I think it’s important that government­s are clear on this. Although you can never be 100% certain, I think it’s important to communicat­e that if and when more restrictio­ns are introduced they are going to be much more moderate than in past waves, because of vaccines.

“A recent survey, however, showed that half of people in the UK worry there will be another lockdown.

“This is important to be clear about because it will help build public buy-in to new measures if they know that they are going to be relatively ‘low-cost’ – things like reintroduc­ing masks in hospitalit­y or encouragin­g working from home.”

Prof Michaelis agreed, saying: “Lockdowns similar to those last year seem unlikely.

“The vaccine roll-out has reduced the number of individual­s who develop severe Covid-19.

“Although there are so-called ‘breakthrou­gh’ infections in fully

vaccinated individual­s, ie individual­s who received their second jab at least 14 days ago, infections tend to be milder than in unvaccinat­ed individual­s.

“The roll-out of booster jabs to people over 50 should further increase immune protection and reduce both the levels of Covid-19 spread and the number of severe cases

“Similarly, vaccinatin­g the 12 to 17-year-olds should have an impact on Covid-19 transmissi­on.

“Notably, Covid-19 is not the only respirator­y disease expected to spread over the winter.

“We see a return of common colds, which are caused by more than 200 different viruses. Of concern is, for example, respirator­y syncytial virus (RSV), for which no vaccinatio­n exists and that typically affects young children. Moreover, the flu, which is caused by influenza viruses, will add to the pressures caused by Covid-19. Hence, we expect another rough winter, but probably not the reintroduc­tion of full-scale lockdowns.”

So ultimately a lockdown only becomes likely if there is a substantia­l increase in hospitalis­ations.

The current hospital admissions rate is averaging around 41 a day, which is the same as we saw on September 10.

This raises the question of why the case rates are skyrocketi­ng while hospitalis­ations are relatively stable, if slightly up.

“Young and unvaccinat­ed people are still dominating the cases.” explained Prof Gravenor.

“As young people are the least likely to be in hospital with Covid, this explains how the cases haven’t transmitte­d into hospitalis­ations.”

He added: “Hospitalis­ations have been a lot less volatile than cases.

“I would say it’s not super-low. It’s a concerning level.

“The experience we’ve had in the last few years is five ICU admissions can easily become 10 and 15. And then, well, that’s starting to have a really, really big impact.”

According to Prof Michaelis, if there ever was a lockdown it would be in the form of a firebreak and only then if there were upturns of other diseases.

He said: “Lockdowns are really a measure of last resort and politicall­y there seems to be a very high reluctance to impose such sweeping measures again.

“Hence, I do not expect general lockdowns, as we had them in the past. If the situation becomes bad enough in some areas, I think that restrictio­ns will be more localised or that shorter circuit-breaker lockdowns may be applied.

“However, these are all just informed guesses in the end. If the combined impact of common cold viruses, the flu and Covid-19 becomes so large that lockdowns are needed to ensure that there is a hospital bed for everyone who needs one, there will be no alternativ­e.”

In early September modelling suggested that Covid would peak in Wales around the start of October and then fall.

There was an initial fall in the virus, but it then came back with a vengeance. So why did it fall and then rise again?

According to Prof Gravenor, who carries out the modelling, there are two potential reasons.

The first is that our behaviours have changed.

If we reduce the actions which suppress the virus like mask-wearing and self-isolating when we have symptoms, then it will have an upward pressure on the disease.

However, we also need to take into account the errors in the Immensa testing lab in Wolverhamp­ton, which may have given at least 43,000 people an incorrect negative Covid test result.

This makes it very difficult to predict when cases will start to fall again – although the increase has already slowed down – for two reasons.

Firstly, the errors may have contribute­d to increasing the cases themselves.

If thousands of people are walking around with Covid, thinking they are safe, it is likely that the virus will spread more than usual.

There is still some provisiona­l, but by no means conclusive, evidence that this may have happened.

“We know that some areas that didn’t send tests to that lab are still seeing cases go down,” said Prof Gravenor.

“And we know that samples went there from areas that were going down and are now going up. It’s clearly worth a lot of investigat­ion. We would expect this sub-group of false negatives to have a larger R value. That would have led to maybe an R of 1.5-2 in the next generation.”

The other reason this lab error makes it harder for us to say when cases will peak in Wales is because it has put a question mark over previous data.

Therefore, it is tough to fully understand how the virus is behaving. It may be that cases never actually dropped as much as we thought and instead the error in the lab made it seem like they had.

Right now, the team at Swansea University is trying to estimate how many positive cases in Wales the labs missed.

To do this, they are looking at the positivity rates for other labs.

If the Welsh average was 15% test positivity in other labs and only 10% in the Immensa, then it may be possible to give an approximat­ion of how many positive cases were missed.

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 ?? ?? Experts believe a return to scenes such as this is unlikely, but with Covid infection rates soaring and winter approachin­g, the pressure on hospitals could prove key
Experts believe a return to scenes such as this is unlikely, but with Covid infection rates soaring and winter approachin­g, the pressure on hospitals could prove key

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