The Daily Telegraph

Risk of brain damage in Mars mission

- By Sarah Knapton SCIENCE EDITOR

NASA may need to invent a spaceship with artificial gravity before humans can venture to Mars, after a new study found weightless­ness causes worrying changes in the brain.

The mission would be fraught with technical challenges, but the real difficulti­es may lie in getting astronauts there with their minds intact.

Alarming new research, funded by Nasa, has found that microgravi­ty causes astronauts’ brains to shift upwards and become squashed at the top of the skull, piling pressure on vital neural regions.

Crucially, the parts of the brain most affected – the frontal and parietal lobes – control movement and higher executive function, which are essential for attention, focus, planning, organising and rememberin­g details. They are also the regions linked to pro-social behaviour, which help people avoid making hurtful or inappropri­ate comments.

Researcher­s at the Medical University of South Carolina (MUSC) said urgent work was needed to gauge the impact of brain damage and find out how long it lasted after a mission, particular­ly as companies are already planning on taking civilians into space.

Dr Michael Antonucci, at the department of radiology and radiologic­al science at MUSC, said: “Any change to a region of the brain that controls the way we sense our environmen­t and our ability to interact with it raises concerns. There are some medication­s that are used to treat patients with increased pressure on earth. However, how these would work in microgravi­ty is uncertain. Designing a space vehicle with artificial gravity might be a way of minimising changes.”

Although artificial-gravity still lies firmly in science fiction, theoretica­lly, spinning a space station would create enough centrifuga­l force to create the effect of being pinned to the surface.

For this study, the team examined the brains of participan­ts who stayed in bed for 90 days, and were required to keep their heads tilted downwards to simulate the effects of microgravi­ty.

They also checked brain scans from 18 astronauts who spent a few weeks aboard Nasa’s space shuttle, and compared them with 16 astronauts who had spent an average of three months in the Internatio­nal Space Station.

Brain scans showed a narrowing of the bumps and depression­s in the brain folds in the bed-ridden participan­ts, 94 per cent of the ISS astronauts, but only 18 per cent of the shuttle crews. There was also evidence of brain shifting up into the inner roof of the skull.

A journey to Mars can take three to six months, and crews would be expected to stay for two years until planetary alignment allowed for a journey home. It means crews would be in reduced gravity for around three years.

To date, the longest continuous time in space was 438 days, a record held by Russian cosmonaut Valery Polyakov.

The research was published in the New England Journal of Medicine.

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