The Mail on Sunday

OCD pills could be weapon in the war on obesity

- By Paul Dinsdale

A COMMON antidepres­sant could be used to help people with compulsive eating habits choose healthy food instead of fatty snacks, scientist have claimed.

In a series of trials researcher­s found that when people took citalopram, prescribed for depression and obsessive compulsive disorder (OCD), they were more likely to pick healthy food such as fruit over chocolate biscuits.

Ivo Vlaev, professor of behavioura­l science at Warwick Business School, who led the study, said the discovery could help in tackling the obesity crisis.

Data suggests that 63 per cent of adults in England are overweight or obese – a problem that costs the NHS £5.1 billion a year.

‘These findings also have implicatio­ns for treating eating disorders,’ added Prof Vlaev. ‘We found that citalopram increased the number of choices for

‘People focused on healthier food’

healthy foods made by people when compared to a placebo. Our trials suggest that after taking the drug, people are more likely to make decisions based on health rather than taste.

‘It appears to give people the long-term focus needed to consider how food will impact on their health, rather than the short-term decision to go for what tastes better.’

In the study, researcher­s gave a pill to 27 adults and asked them to choose between pairs of snacks shown on a screen, ranging from fruit to chocolate biscuits. Sometimes there were two healthy options, sometimes two unhealthy foods and sometimes one of each.

The pill was either a single dose of atomoxetin­e, a tablet used to treat attention deficit hyperactiv­ity disorder (ADHD); citalopram; or a dummy pill with no active ingredient­s (placebo).

Citalopram works by lengthenin­g the time the ‘feelgood’ brain chemical (neurotrans­mitter) serotonin is held by the synapse in the cell, so prolonging its action.

The researcher­s found that, when taking citalopram, as much as 60 per cent of the participan­ts’ choices were healthy, while just 45 per cent of them were healthy when taking the placebo. The number of healthy choices made taking atomoxetin­e was not significan­tly higher.

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