The Mail on Sunday

COULD FASTING 16 HOURS EVERY DAY HELP TO KEEP CANCER AT BAY?

- Dr Michael Mosley

OVER the past five pages we’ve revealed the truth about food and cancer. Contrary to popular belief, there is no one thing – whether that’s red meat, bacon, toast, roast potatoes or anything else we eat – that raises the risk significan­tly.

It’s overall diet that really matters. If we eat too much, we end up becoming overweight. But the fact that carrying too much fat, particular­ly around the middle, is linked to cancer is something that still surprises a lot of people.

If you’ve got fat around your tummy, you probably also have quite a lot of visceral fat – that’s the name for fat that builds up inside the abdomen and around the organs.

And it is a problem, because it doesn’t just sit there, wobbling. Visceral fat is active, sending out signals to the rest of your body.

Some of these signals make your cells divide more rapidly, which increases your risk of cancer, while others cause inflammati­on, another big driver of cancer.

According to Cancer Research UK, being overweight or obese leads to about 22,800 new cases of cancer each year.

The cancers which are particular­ly strongly linked to excess fat are breast and bowel, two of our most common forms of the disease.

Cancers of the pancreas, oesophagus and gallbladde­r, all of which are extremely hard to treat, are also linked to obesity.

So keeping to a healthy weight and keeping your tummy trim – ideally your waist should be less than half your height – are great ways to reduce your cancer risk.

And I believe one of the best ways to do this is through intermitte­nt fasting.

It can not only cut your risk of developing cancer but may even boost the effectiven­ess of treatments such as chemothera­py, if you are unlucky enough to need it.

HOW 5:2 COULD HELP FIGHT BREAST CANCER

SEVEN years ago I wrote a book, The Fast Diet, with journalist Mimi Spencer, in which we outlined the potential benefits of going on a 5:2 intermitte­nt fasting diet. This is one where you reduce your calories to about 600 twice a week.

I suggested it would not only help you lose weight, but, according to studies carried out on animals, might also help cut your risk of developing cancer.

Since then, studies in humans have indicated the same.

British scientists Dr Michelle Harvie and Professor Tony Howell have carried out studies that showed intermitte­nt fa sting helped improve insulin resistance in one group of women. Insulin resistance is a measure of how much of the hormone your body has to produce to bring your blood sugars down after a meal.

Another group of women who dieted every day also lost weight, but didn’t see the same insulin improvemen­t. This is important because having high levels of insulin increases your cancer risk.

So a combinatio­n of weight loss and improvemen­t in insulin sensitivit­y could be highly beneficial.

In another more recent study, Dr Harvie asked 23 overweight, pre-menopausal women at high risk of breast cancer to cut back their calories, two days a week, for one menstrual cycle. This time, as well as standard tests, they agreed to have breast biopsies. Over the course of a month, the women lost an average of three kilos (more than 6 lb), most of it body fat.

In most of the women there were significan­t changes in the activity of genes associated with breast cancer.

Bigger studies would be needed to really prove intermitte­nt fasting, rather than weight loss generally, was responsibl­e. But the results are interestin­g.

SKIPPING BREAKFAST COULD BE A GOOD IDEA

IN THE Fast Diet, I also wrote about a different form of intermitte­nt fasting, one called time restricted eating. It’s also known as 16:8, and you don’t worry about calories when doing this plan. Instead, you limit the hours within which you eat your meals.

Many of us don’t finally finish eating and drinking until about 10pm thanks to a late-night snack, and then we start eating again soon after we wake up. That means we go without food for about nine hours.

The idea behind time restricted eating is to extend the length of your ‘ overnight fast’ to 12, 14 or even 16 hours by finishing eating earlier in the evening and starting again much later– basically, skipping breakfast the following day.

It has been shown to help people lose weight. But can it also reduce your cancer risk?

In a large study, 2,400 American women with breast cancer were randomly allocated to either a l ow- fat diet or given general health advice.

They were then followed over the next seven years to see if going on a low-fat diet made any difference to the risk of breast cancer recurring. The answer was a resounding ‘no’.

Despite reducing their fat intake by 19 per cent, the low-fat dieters were no better off than those in the control group.

But the great thing about this study, from the point of view of researcher­s investigat­ing time restricted eating, is that the women were asked to keep detailed records of when they ate.

The women whose diaries showed that they had fasted for more than 13 hours a night had 36 per cent less chance of a breast cancer recurrence than those who had been fasting for under 13 hours.

There is a lot more informatio­n about intermitte­nt fasting, foods and their impact on cancer in my latest book, the Fast 800. You can also find additional informatio­n at thefast800.com.

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