‘Thread of life’ protein could tackle diseases

An anti-ageing protein named after a Greek goddess who spun the thread of life has untapped potential in the treatment of multiple diseases, scientists have discovered.

Understanding the structure of the beta-klotho molecule could lead to new ways of tackling conditions including diabetes, obesity and some cancers, say researchers.

In Greek mythology, Klotho (or Clotho) was one of the three Fates that ruled human destiny. She spun the thread of life, which was cut when it was the right time for a person to die.

The Klotho protein, which can take one of two forms, is found on the surfaces of cells in specific tissues. Studies have shown that it is involved in processes that slow ageing. The molecule binds to a family of hormones that regulate metabolic processes.