The Scotsman

Cells hope for bowel dis­ease

- By JOE GAMMIE Health · Pharmaceutical Industry · Biology · Skin Conditions · Mental Health · Medications · Medicine · Pharmacology · Bacteria · Science · Industries · Health Conditions · Immune Disorders · King's College London · London · Crohn's Disease · Autoimmune Diseases

Rare im­mune cells can drive gut re­pair, pro­vid­ing hope of new treat­ments for pa­tients suf­fer­ing from in­flam­ma­tory bowel dis­eases (IBD) such as Crohn’s dis­ease, a study has found.

In a pa­per pub­lished in Na­ture Ma­te­ri­als yes­ter­day, the team of re­searchers from King’s Col­lege Lon­don said that type-one in­nate lym­phoid cells (ILC1) can pro­mote tis­sue re­pair.

The au­thors said that it had pre­vi­ously been as­sumed the ILC1 cells drove in­flam­ma­tion, so the find­ings could in­spire com­pletely new ther­a­peu­tic ap­proaches for those suf­fer­ing from IBDS such as such as Crohn’s dis­ease and ul­cer­a­tive col­i­tis. But the study also found when they ac­cu­mu­late in in­flamed tis­sues, the cells can also con­trib­ute to IBD co­mor­bidi­ties such as cancer and fi­bro­sis.

Lead au­thor PhD stu­dent Geral­dine Jowett said the find­ings had come as a sur­prise.

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