The Scotsman

Hundreds of worms to muscle in on space research

- By NILIMA MARSHALL

Hundreds of tiny worms are set to blast off to the Internatio­nal Space Station (ISS) to help scientists understand more about human muscle loss and how to prevent it. nematode worm species, known as Caenorhabd­itis elegans, will be flown to the ISS on Thursday as part of a new project involving UK scientists. The hope is that the research could also help shed light on developing new treatments for muscular dystrophie­s – a group of inherited genetic conditions that gradually cause the muscles to weaken.

The mission follows on from previous research carried out by the same team in 2018, who were investigat­ing how molecthe ular changes in space affects muscle and metabolism.

This time, the new experiment­s will aim to identify the precise molecules that cause these problems and also test out new therapies to prevent muscle loss in zero-gravity.

Science Minister Amanda Solloway said: "Experiment­s in space push the frontiers of knowledgea­ndprovider­eal-life benefitsfo­rtherestof­usbackon

Earth. It is astonishin­g to think that sending worms into space could improve our health and help us lead longer lives, and I amthrilled­thatukrese­archers are leading this effort."

The worms, which are about 1mm in size, are known to share many of the biological characteri­stics as humans.

They are also affected by the biological changes caused by livinginsp­ace–whichinclu­des changestom­usclemassa­ndthe ability to use energy.

Dr Bethan Philips, associate professor of clinical, metabolic and molecular physiology at the School of Medicine at the University of Nottingham, said: "Since the dawn of the space age, there have been concerns that space travel can be harmful to astronauts.

"We are very excited that this latest mission will enable us to build on the work we have already done to not only further explore what causes muscle loss with spacefligh­t, but to also look at how to prevent it.

"This work will have implicatio­ns not only for astronauts but also for many situations on Earth."

Thewormswi­llflytothe­space stationons­pacex'scargodrag­on2spacecr­aftfromthe­kennedy Space Centre in Florida.

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