Risk of Covid infection in vaccinated rises over time
Experts who have been tracking the effectiveness of the Pfizer/biontech vaccine have found that the risk of Covid infection increases the longer it is since people had a second dose.
The study backs up the need for booster doses to prevent people suffering breakthrough infections as immunity wanes, according to the team, who published their findings in the British Medical Journal (BMJ).
Experts from the Research Institute of Leumit Health Services in Israel found a gradual increase in the risk of Covid-19 infection from 90 days after people received a second dose of the Pfizer/biontech vaccine.
Israel was one of the first countries to roll out a large scale Covid-19 vaccination campaign in December 2020, but has been battling a resurgence in infections and has been looking closely at waning immunity.
The experts examined electronic health records for 80,057 adults (with a average age of 44) who had a PCR test between mid-may and September at least three weeks after their second vaccine injection.
None of the people in the sample had evidence of previous Covid-19 infection. Of the group of 80,057 people, 7,973 (9.6 per cent) had a positive test result.
The study found that the rate of positive results was found to rise in line with the time since people had had their second dose.
Across all age groups, 1.3 per cent of people tested positive 21-89 days after a second dose, but this increased to 2.4 per cent after 90-119 days; 4.6 per cent after 120-149 days; 10.3 per cent after 150-179 days; and 15.5 per cent after 180 days or more.
Compared with the first 90 days after a second dose, the risk of infection across all age groups was 2.37-fold higher after 90-119 days; 2.66-fold higher after 120-149 days; 2.82fold higher after 150-179 days; and 2.82-fold higher after 180 days or more.
While the study is observational in nature, the experts said it appears clear that immunity wanes after the first three months of being double-vaccinated. They said: "Large scale Covid-19 vaccination campaigns can achieve control over the spread of the virus, but even in countries with high vaccination rates, breakthrough infections can occur.
"The risk of (Covid) infection in adults who received two vaccine injections increased with time elapsed since vaccination compared with the reference (individuals vaccinated in the last 90 days)."
Astrazeneca has said antibody protection from its vaccine also wanes, alth ough its chief executive, Pascal Soriot, said on Tuesday that the jab is thought to offer long-term T-cell immunity for older people,
which could be better than other vaccines. Meanwhile, the UK Government Department of Health and Social Care said people who have had their booster vaccine by 11 December will have "very high protection
against Covid-19 by Christmas Day". Research has shown that two wee ks after a booster, people have a very high level of protection.