Cloning ‘didn’t give Dolly the sheep arthritis’

EARLY FEARS that cloning may have given Dolly the Sheep arthritis were unfounded, say scientists.

Dolly, born at the Roslin Institute in Edinburgh in 1996, made history by being the first mammal to be cloned from an adult cell. There have been claims the process led her to age prematurely and left her vulnerable to diseases linked to ageing.

Dolly died on February 14, 2003, aged six. One affliction she was thought to have suffered was early-onset osteoarthritis (OA), resulting in her joints wearing out before their time.

But a new X-ray examination of Dolly’s skeleton found no evidence of abnormal oestoarthritis.

The same was true of the bones of Dolly’s naturally conceived daughter Bonnie, and Megan and Morag, two other sheep clones created from cultured cells.

Professor Sandra Corr, from the University of Glasgow, said: “We found that the prevalence and distribution of radiographic OA was similar to that observed in naturally conceived sheep and our healthy aged cloned sheep.

“As a result we conclude that the original concerns that cloning had caused early-onset OA in Dolly were unfounded.”

The only formal record of osteoarthritis in Dolly was a brief

mention in a conference abstract, said the researchers, whose findings are reported in the journal Scientific Reports.

It reported that Dolly had OA of the left knee.

It was earlier reported that Dolly the sheep continues to inspire research 20 years after she was revealed to the world.

Treatments for conditions like Parkinson’s disease are still influenced by her creation.