Rams 49ers at Chiefs Bills at Cardinals Cowboys

8:20 p.m. 5 p.m. Monday 8:15 p.m. Monday

Los Angeles has scored an opening-drive TD in four of five games this season. QB Jared Goff is 20 for 21 for 250 yards and one TD on the first drive of games. ... The Rams are tied for the NFL lead with 20 sacks.

The game features two of NFL’S top passers, with Buffalo’s Josh Allen second in the league with 1,589 yards, and Kansas City’s Patrick Mahomes fourth (1,474). ... RB Clyde EdwardsHelaire leads rookies with 344 yards rushing.

The Monday night debuts for Cardinals QB Kyler Murray and coach Kliff Kingsbury will also be their first NFL appearances in their home state, in a familiar venue for both. ... Murray is 6-0 at the home of the Cowboys.

The 49ers opened the season 0-3 at home for the fourth time since merger. ... San Fran has a league-low 38 catches and 480 yards receiving from WRS this season. … Raheem Mostert leads all RBS averaging 7.0 yards per carry.

Bills coach Sean Mcdermott is 1-0 against his mentor and former boss, Kansas City’s Andy Reid. ... QB Josh Allen is first player to top 1,500 yards passing with 14 passing TDS and three rushing through the first five games of a season.

The Cowboys have gone from 3-point favorites to 2-point underdogs after QB Dak Prescott’s season-ending ankle injury. ... Andy Dalton is making first start filling in for Prescott a few miles from where he had standout career at TCU.

Line: Rams by 3 Pick: Rams, 24-21

Line: Chiefs by 41⁄ Pick: Chiefs, 30-28

Line:

1

Pick: Cowboys, 26-23

Cardinals by