Baltimore Sun

In Ebola vaccine, a long shot holds hope

WHO plan simple but execution hard in rural areas

- By Sam Mednick and Lauran Neergaard

MBANDAKA, Congo — Irene Mboyo Mola spent 11 days caring for her husband as he died of Ebola in a hospital where she said nurses were too scared to get close.

She helped him to the bathroom, picked up his feverish body when he lost his balance, and reinserted an IV that fell out of his bleeding arm.

“He told me all he could see was death,” recalls Mola, a 30-year-old mother of six, as she sat slumped on the floor in her small hut.

That close contact put Mola at high risk of getting a disease that has no cure and kills about half of those infected.

But now, as Congo battles the most serious Ebola outbreak since the devastatin­g 2014 epidemic in West Africa, health workers have something new to offer — a vaccine.

With thousands of doses dispatched to front-line health workers, the world is watching to see if a promising but still experiment­al vaccine might help stop this terrifying disease faster than traditiona­l measures doctors have tried since Ebola was identified 40 years ago.

Even if the vaccine helps, there are serious hurdles.

The shots must be transporte­d deep into forests with few paved roads without it spoiling in the heat.

Health workers have to identify and track down anyone who’s had contact with a sick person.

Hardest of all, they must persuade a scared and wary population that shots pushed by foreigners could save their lives. A WHO staffer holds a used Ebola vaccine vial. Success hinges on the speed at which health workers find those at risk.

“Communitie­s themselves must be at the center of the response if the activities are going to be effective,” said Jonathan Polonsky of the World Health Organizati­on, a surveillan­ce coordinato­r in Mbandaka, a city of more than 1 million in northweste­rn Congo.

Mola’s six children have all been vaccinated. But she refused, telling government social workersand­WHOworkers that she didn’t believe her husband died from Ebola. She said the hospital never showed her records confirming he’d tested positive for the virus.

There’s no guarantee the long-sought vaccine will help stop the outbreak. But Congo’s health ministry and the WHO rushed in 7,500 doses, created by the Public Health Agency of Canada and owned by Merck.

It was deemed the best option because the vaccine was found highly promising in testing a few years ago, when the epidemic in West Africa, which killed more than 11,000 people between 2014and201­6, wasstartin­g to wane.

The plan: What’s called “ring vaccinatio­n,” to find and vaccinate everyone who’shaddirect contact with a sick person — the first “ring” — and then contacts of those people, too, to break the chain of infection.

Last month, 11-year-old German Umba and her 6year-old brother lost their father to Ebola. Both were vaccinated.

But a shot alone doesn’t end the worry. U.N. workers monitor the children several times a day for fevers, an early symptom, until the incubation period passes.

Standing in the yard outside her classroom at school the young girl suddenly bursts into tears. Surrounded by aid workers, classmates and teachers who are unable to touch and console her, she buries her face in her shirt.

“I just miss my father,” she says.

Success with the vaccinatio­n strategy hinges on the speed at which health workers can identify people at risk.

“If you detect cases late, you’re missing the opportunit­y to protect people,” said Dr. Iza Ciglenecki, working on the vaccinatio­n campaign with Doctors Without Borders.

Congo’s current outbreak has killed 14 people so far, according to the country’s Ministry of Health. There have been 38 confirmed infections.

WHO emergency response chief Peter Salama said Friday that many people vaccinated in Mbandaka received the shots morethan10 days ago, meaning they’re now protected — the vaccine has had time to kick in.

Finding people who need vaccinatio­n is much harder in the remote area of Iboko, where a new case was just reported. Shoddy infrastruc­ture adds to the challenge.

“The roads are so bad that even if a person gets vaccinated, it can be too late, and they can still die,” said Rosy Boyekwa Yamba, a regional representa­tive for the Ministry of Health in Mbandaka.

It can take days to travel just 100 miles to reach remote areas where Ebola still is spreading. The vaccine must be kept at a temperatur­e of minus 76 to minus 112 degrees Fahrenheit, and can only be kept in mobile freezers for up to seven days.

Yamba also worries that potentiall­y infected people aren’t being found.

Five such people came forward last week in Mbandaka after he pleaded with community members to “be honest with him” about whether they’d been in contact with someone who had the disease.

So far more than 2,000 people, including front-line health workers, have been vaccinated in Mbandaka and the rural villages of Bikoro and Iboko where confirmed cases have been found, says the Congo’s Ministry of Health.

Mola’s refusal to believe that Ebola killed her husband is a common reaction in the region. While many in Mbandaka have taken to washing hands and avoiding physical contact amid the outbreak, many also remain skeptical.

They often don’t trust a government they say is corrupt.

Of the dozens of people The Associated Press spoke to on a recent visit, nearly all said they don’t believe Ebola exists and referred to it as witchcraft.

This is Congo’s ninth outbreakbu­tillnesses are usually in remote areas, not cities.

“Ebola is not here,” said local resident Aziza Monzu. “It’s a disease created by organizati­ons to get money.”

Dr. Pierre Rollin, an Ebola expert with the U.S. Centers for Disease Control and Prevention, understand­s.

“People die every day and everywhere, but nobody’s interested. Suddenly because of Ebola people are interested and that makes you suspicious,” he said. “Why would they trust us?”

Mola seems to have escaped infection. The incubation period for Ebola is up to 21 days, and her husband died three weeks ago. “I’m still here,” she said. Still, WHO officials say three quarters of those who have been approached have agreed to a shot since the campaign started two weeks ago.

Once you’ve got people on board “you’ve tackled 90 percent of the problem,” said Dr. Alhassane Touré, the WHO coordinato­r for ring vaccinatio­n in Congo and Guinea.

 ?? SAM MEDNICK/AP ??
SAM MEDNICK/AP

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