Call & Times

Billionair­e doctor’s $11,000 cancer test has few takers

- By CAROLINE CHEN

A health-care company founded by the world's richest doctor is struggling to get paid for an $11,000 diagnostic test, the latest challenge to the billionair­e's quest to conquer cancer.

NantHealth Inc.'s GPS Cancer, which purports to be the "nation's first comprehens­ive molecular test of tumor and normal-tissue measuring," goes beyond other DNA sequencing tests in the market by providing informatio­n on protein expression levels and RNA, genetic messengers that transcribe DNA code into instructio­ns for making proteins. It's a key in founder Patrick Soon-Shiong's ambitious approach to treating cancer.

NantHealth reported a combined 670 "commercial orders" for the tests in the second half of last year. Those numbers suggest a robust launch, but Bloomberg News, checking with each of the insurers that covers the test, has only confirmed that six were ordered and paid for, all from Sanford Health, a hospital system in the Dakotas. It isn't clear how many of the other 664 ordered tests insurers will pay for or NantHealth has already given away.

NantHealth spokeswoma­n Jen Hodson did not dispute Bloomberg's findings and said that any tests not ordered by payers would have been ordered by community oncologist­s. While this shows doctor interest, it suggests NantHealth is giving away the vast majority of the commercial­ly ordered tests.

"We will not turn away a patient or physician that wants to order GPS," said Hodson in an email. "That said, it does create a lag on reimbursem­ent if the underlying insurance of the patient is not one of our contracted employers or payers."

NantHealth reported $100.4 million in 2016 revenue but didn't break out how much came from the diagnostic tests. The company also sells various software services to payers and hospitals.

"They seem to distribute an extraordin­ary number of tests that aren't paid for," said Paul Knight, an analyst at Janney Montgomery Scott who covers the diagnostic industry. Giving away tests to doctors to get the word out and generate demand is common among genomics startups but NantHealth's numbers are "unusual" and show that the test is "a long way from being commercial­ly viable."

Some investors are losing confidence, driving down NantHealth shares 67 percent since the beginning of the year.

The payment questions come as Soon-Shiong, who is worth $8.6 billion according to the Bloomberg Billionair­es Index, has been promoting the advances of a dozen or so companies he's launched to wage his cancer-fighting campaign. He said he's raised more than $1.8 billion from investors, but despite this success, his companies have been the focus of media reports that have suggested aggressive marketing techniques, selfdealin­g and over-hyped claims.

Reports in Politico and Stat News have detailed SoonShiong philanthro­pic gifts to entities that have business deals with his for-profit companies. The billionair­e also came under fire recently for advertisin­g videos touting NantKwest Inc.'s experiment­al cancer drug as a "breakthrou­gh," even though it's only in early-stage trials. Nanthealth said it found "multiple inaccuraci­es" in the Stat News report. It didn't respond to a request for comment on the Politico story.

Marketing the NantHealth test comes amid a groundswel­l of other companies seeking to offer diagnostic tests to sequence cancer tumors. As scientists are increasing­ly able to identify genetic mutations responsibl­e for tumors, drugmakers are developing treatments aimed at specific mutations, creating a market for diagnostic­s companies to help sort patients by tumor type.

The billionair­e has said his test is the most comprehens­ive on the market and enables "the doctor and the patient to have the most informed decision before treatment begins." While other tests on the market focus only on mutated DNAthat fuels cancer growth, Soon-Shiong's argument is that additional informatio­n about the levels of proteins in patients' tumor cells can supplement the DNA informatio­n and better guide treatment.

It's a nascent field, and companies besides NantHealth have struggled to get reimbursed for tests at even half the cost. And though NantHealth touts that it's signed on eight insurers and employers who say they'll use the tests, they aren't rushing to place orders.

Insurer Horizon Blue Cross Blue Shield, for instance, said it has agreed to run a pilot study for 160 plan members but hasn't yet ordered any tests. Allen Karp, senior vice president of healthcare management notes the study hasn't started yet.

Similarly, Phoenix Children's Hospital has signed a deal to cover the test for its employees, but hasn't ordered any yet.

 ?? Patrick T. Fallon/Bloomberg ?? Patrick Soon-Shiong, founder and chief executive officer of NantHealth, at the annual Milken Institute Global Conference in Beverly Hills, California.
Patrick T. Fallon/Bloomberg Patrick Soon-Shiong, founder and chief executive officer of NantHealth, at the annual Milken Institute Global Conference in Beverly Hills, California.

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