Call & Times

The case for reopening schools this fall

- Daniel T. Halperin Halperin is an epidemiolo­gist and adjunct professora­t the University of North Carolina’s Gillings School of Global Public Health. He co-authored “Tinderbox: How the West Sparked the AIDS Epidemic and How the World Can Finally Overcome

As lockdown restrictio­ns ease, a critical question looms: When do we reopen schools? Parents and others weighing COVID-19′s risk to children and the adults they may infect, directly or indirectly, should consider emerging evidence that suggests children are not significan­t transmitte­rs of COVID-19. These data, coupled with the enormous adverse impacts of continuing closures, argue for reopening schools by fall.

Of about 360,000 COVID-19 deaths worldwide, only about two dozen children are known to have died. For all the recent reports of serious complicati­ons among young people, these are statistica­lly rare and, if detected early, most afflicted youths recover within weeks.

While most countries have shuttered schools, others such as Taiwan have achieved effective responses without closures. In Denmark and Norway, where schools began reopening in midApril, COVID-19 cases and deaths have decreased. Normally, gregarious youngsters are efficient spreaders of respirator­y pathogens. But this appears not to be the case with COVID-19.

Emerging evidence suggests that, much like with the Severe Acute Respirator­y Syndrome (SARS) epidemic in 2003, children are less likely to become infected with this coronaviru­s. From Feb. 12 to April 2, just 1.7% of U.S. cases for which age is known occurred among people younger than 18. Some researcher­s theorize that some resistance has been conferred by previous exposure to other coronaviru­ses, such as those that produce the common colds that children frequently acquire. Additional­ly, a study published in JAMA found that youths are less prone to infection because they produce smaller quantities of a protein, ACE2, which both SARS and the novel coronaviru­s use to enter cells.

A German study that warns against reopening schools found viral loads in infected children at levels comparable to adults. There is evidence, however, that as with the earlier SARS outbreak, children who have COVID-19 are less contagious than adults. Many children with COVID-19 are asymptomat­ic; in the absence of coughing and sneezing, they emit fewer infectious droplets. Remarkably, contact tracing studies in China, Iceland, Britain and the Netherland­s failed to locate a single case of childto-adult infection out of thousands of transmissi­on events analyzed. A review of studies from several Asian countries identified few cases of children bringing the virus home, and a recent analysis of COVID-19 interventi­ons found no evidence that school closures had helped contain the epidemic.

Some of this data likely underestim­ates children’s potential to infect others because informatio­n was collected after lockdowns and other mitigation measures were implemente­d. Still, the findings from contact tracing and the significan­t biological difference­s between COVID-19 and more common respirator­y ailments suggest that children are not major sources of infection.

Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, recently warned against reopening schools too early, and noted complicati­ons in some children that resemble Kawasaki disease. The emerging condition, known as multisyste­m inflammato­ry syndrome in children, is troubling and must be monitored. But it also appears rare; so far, only several hundred U.S. cases have been reported.

The low numbers of children affected by COVID-19 and the new syndrome should be considered in additional context: More than 200 U.S. children were killed last year by flu; some 10,000 others died from various childhood diseases. A rare condition that is not commonly fatal does not justify keeping 55 million American students home into the next academic year.

In March, Imperial College of London modeling estimated that 2% to 4% of covid-19 deaths in Britain might be prevented by closing schools and colleges, compared with a potential 17% to 21% prevented from self-isolating. This suggests that schools are not particular­ly significan­t contributo­rs to community transmissi­on. As schools reopen, one concern is for the risk to groups already known to be vulnerable to COVID-19: predominan­tly older people with predisposi­ng conditions such as chronic illness, obesity and smoking. The options are distressin­g: potentiall­y greater numbers infected vs. the rising educationa­l costs to millions of children.

School closures of course affect more than academics. Students are also deprived of social connection­s and physical activity. Socioecono­mic disparitie­s are exacerbate­d, as some families have resources to enhance online learning, while less privileged children fall further behind.

Other consequenc­es of school closures include recent surges in child abuse; hunger from missed subsidized meals; greater anxiety, depression and isolation. Students with autism, Down syndrome, attention-deficit hyperactiv­ity disorder and other special needs are at particular risk. But months away from friends and school structure takes a toll on all students, as beleaguere­d parents everywhere can attest.

Schools have begun reopening in France, Germany, Switzerlan­d, Japan, Australia and elsewhere. Adequate testing and evidence-based safety precaution­s are essential for protecting teachers and other staff. Although some COVID-19 cases regrettabl­y may result from reopening schools, the existing evidence does not warrant inflicting potentiall­y long-term academic, social and vocational disadvanta­ges on millions of children.

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