Chattanooga Times Free Press

Cannabinoi­ds subject of scientific inquiry

- Dr. Eve Glazier Eve Glazier, M.D., MBA, is an internist and associate professor of medicine at UCLA Health. Send your questions to askthedoct­ors@mednet.ucla.edu, or write: Ask the Doctors, c/o Media Relations, UCLA Health, 924 Westwood Blvd., Suite 350,

DEAR DOCTOR: How are medical marijuana and CBD oil different from each other? Some states don’t allow sale of the former but do allow the latter. I ask because an over-the-counter CBD oil, which does not contain THC, stopped my microscopi­c colitis within two days.

DEAR READER: Marijuana, also known as cannabis, is best known for producing buds and leaves that contain THC, or tetrahydro­cannabinol, the compound that gets you high when smoked or ingested. When people talk about medical marijuana, they’re referring to cannabis that, due to state laws, is legally for sale to individual­s with a medical recommenda­tion. Medical marijuana is legal in 30 states and in Washington, D.C. At the federal level, however, cannabis is a controlled substance that is illegal.

When it comes to the cannabis plant, the THC that gets you high is just one of about 80 similar chemical compounds found within its resin. Known as cannabinoi­ds, they produce a range of druglike effects within the body. One of those compounds is cannabidio­l, or CBD. Unlike THC, it does not have psychoacti­ve properties. It has been shown to be effective in treating certain forms of childhood epilepsy. There is also evidence that it can be helpful for people dealing with

anxiety issues. CBD oil has also shown promise in recent studies looking into its effects in cancer treatment, Type 1 diabetes, sleep disorders, Parkinson’s disease and seizure disorders.

The challenge with CBD oil is that, since it is technicall­y illegal, there is no federal oversight or regulation for its production. Although it is sold in a variety of forms and a range of concentrat­ions, none of them have been approved by the Food and Drug Administra­tion. At this time, 17 states have laws that address CBD sales and usage, but not all of them oversee production.

Many of the claims made by users remain unproven, and potential side effects or ill effects of its use over time remain largely unknown. The good news is that cannabinoi­ds have shown promise in a number of therapeuti­c uses and have become the subject of widespread scientific inquiry.

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