Chattanooga Times Free Press

Amgen to buy the Irish drugmaker Horizon Therapeuti­cs in $26.4B deal

- BY TOM MURPHY

Amgen is spending more than $26 billion to dive deeper into rare disease treatments with the acquisitio­n of drugmaker Horizon Therapeuti­cs.

The biotech drug developer said Monday that it will pay $116.50 in cash for each share of Horizon, which makes a treatment for thyroid eye disease that generated more than $1 billion in its first full year on the market.

U.S.-traded shares of the Irish company had already soared about 30% since it confirmed late last month that it had begun “highly preliminar­y discussion­s” about an acquisitio­n with Amgen, the French drugmaker Sanofi, and Johnson & Johnson’s Janssen division.

Amgen had confirmed discussion­s were taking place and said that any offer it made for Horizon likely would be in cash.

The deal laid out Monday represents a premium of 48% to Horizon’s closing price of $78.76 before it made that lateNovemb­er announceme­nt.

The Horizon deal will give Amgen another chance to build its portfolio of rare-disease treatments after it closed in October a roughly $3.7 billion acquisitio­n of ChemoCentr­yx, which focuses on autoimmune disease drugs.

Horizon Therapeuti­cs PLC, based in Dublin, develops potential treatments for rare, autoimmune and severe inflammato­ry diseases. Its best-seller, Tepezza, is only approved in the United States and treats eye bulging and double vision from thyroid eye disease.

U.S. regulators approved Tepezza in early 2020 as the first treatment for thyroid eye disease. The drug’s sales more than doubled last year to $1.67 billion. That’s about half of the company’s total sales of $3.23 billion.

The FDA gave Tepezza “orphan drug” status, which comes with financial incentives and exclusive marketing, benefits that are intended to encourage drugmakers to develop rare disease treatments.

Horizon also makes Krystexxa for uncontroll­ed gout. Sales of that treatment grew 39% last year to $565.5 million.

 ?? AP FILE PHOTO/MARK J. TERRILL ?? Amgen headquarte­rs is in Thousand Oaks, Calif.
AP FILE PHOTO/MARK J. TERRILL Amgen headquarte­rs is in Thousand Oaks, Calif.

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