KEYTRUDA IS A BREAKTHROUGH IMMUNOTHERAPY.

KEYTRUDA may be your first treatment for advanced NSCLC, either in combination with chemotherapy or used alone as a chemotherapy- free option. Ask your doctor if KEYTRUDA is right for you.

KEYTRUDA is a prescription medicine used to treat a kind of lung cancer called non– small cell lung cancer ( NSCLC).

KEYTRUDA + CHEMOTHERAPY, NONSQUAMOUS It may be used with the chemotherapy medicines pemetrexed and a platinum as your first treatment when your lung cancer has spread ( advanced NSCLC) and is a type called “nonsquamous” and your tumor does not have an abnormal “EGFR” or “ALK” gene. KEYTRUDA + CHEMOTHERAPY, SQUAMOUS

It may be used with the chemotherapy medicines carboplatin and either paclitaxel or paclitaxel protein- bound as your first treatment when your lung cancer has spread ( advanced NSCLC), and is a type called “squamous.”

KEYTRUDA USED ALONE, PD- L1 POSITIVE

It may be used alone as your first treatment when your lung cancer has not spread outside your chest ( stage III) and you cannot have surgery or chemotherapy with radiation, or your NSCLC has spread to other areas of your body ( advanced NSCLC), and your tumor tests positive for “PD- L1”

and does not have an abnormal “EGFR” or

“ALK” gene.

KEYTRUDA AFTER CHEMOTHERAPY, PD- L1

POSITIVE It may also be used alone for advanced NSCLC if you have tried chemotherapy that contains platinum and it did not work or is no longer working and, your tumor tests positive for “PD- L1” and if your tumor has an abnormal “EGFR” or “ALK” gene, you have also received an “EGFR” or “ALK” inhibitor medicine that did not work or is no longer working.

PD- L1 = programmed death ligand 1; EGFR = epidermal growth factor receptor; ALK = anaplastic lymphoma kinase.

IMPORTANT SAFETY INFORMATION

KEYTRUDA is a medicine that may treat certain cancers by working with your immune system. KEYTRUDA can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life- threatening and can lead to death. These problems may happen any time during treatment or even after your treatment has ended. Call or see your doctor right away if you develop any symptoms of the following problems or these symptoms get worse:

• Lung problems ( pneumonitis). Symptoms of pneumonitis may include shortness of breath, chest pain, or new or worse cough.

• Intestinal problems ( colitis) that can lead to tears or holes

in your intestine. Signs and symptoms of colitis may include diarrhea or more bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; or severe stomach- area ( abdomen) pain or tenderness.

• Liver problems, including hepatitis. Signs and symptoms of liver problems may include yellowing of your skin or the whites of your eyes, nausea or vomiting, pain on the right side of your stomach area ( abdomen), dark urine, or bleeding or bruising more easily than normal.

• Hormone gland problems ( especially the thyroid,

pituitary, adrenal glands, and pancreas). Signs and symptoms that your hormone glands are not working properly may include rapid heartbeat, weight loss or weight gain, increased sweating, feeling more hungry or thirsty, urinating more often than usual, hair loss, feeling cold, constipation, your voice gets deeper, muscle aches, feeling very weak, dizziness or fainting, or headaches that will not go away or unusual headache.

• Kidney problems, including nephritis and kidney failure.

Signs of kidney problems may include change in the amount or color of your urine.

• Skin problems. Signs of skin problems may include rash, itching, blisters, peeling or skin sores, or painful sores or ulcers in your mouth or in your nose, throat, or genital area.

• Problems in other organs. Signs and symptoms of these problems may include changes in eyesight; severe or persistent muscle or joint pains; severe muscle weakness; low red blood