Chicago Sun-Times

WHY KEEPING SCORE COUNTS

Why cholestero­l tests can help you greatly reduce heart, stroke risk

- BY SANDRA GUY For the Sun- Times

If cholestero­l numbers make your head spin, doctors say here’s the bottom line: Get tested ASAP to find out your “bad” cholestero­l number because your long- term health may depend on it.

Everyone should get their cholestero­l checked — and children no later than ages 8 to 11 — to identify a potentiall­y fatal genetic cholestero­l disorder that can be cured with early treatment. The checkups should continue every four to six years, according to the American Heart Associatio­n.

The effort will be worth it because most Americans’ bad cholestero­l — the so- called “lousy” or LDL cholestero­l — is too high and puts them at increased risk of cardiovasc­ular disease, studies show.

And one in 250 Americans inherits even higher levels of bad cholestero­l, called familial hyperchole­sterolemia.

Armed with your personal cholestero­l informatio­n, you have far greater control over your risk of heart attack or stroke than you may realize, even if you inherit the higher levels, experts say. Heart disease and stroke are America’s No. 1 and No. 4 killers, respective­ly.

A healthy lifestyle can cut your risk in half, even though people with the inherited high cholestero­l still require drug treatment, said Dr. Jennifer Robinson, a professor in the college of public health at the University of Iowa and the incoming president of the National Forum for Heart Disease and Stroke Prevention.

“Usually, age 50 is where people’s lifestyles or their genes are catching up with them,” Robinson said. “We often need at that point to turn to preventive drug therapy that’s safe and generic.”

What’s a healthy lifestyle? The ideal goal includes:

† Control the portions you eat, keeping in mind that one portion is half a cup;

† Eat as many as five fruits and vegetables each day;

† Avoid white carbs like white bread and rice;

† Avoid processed foods that are more likely to include saturated fat and high fructose corn syrup;

† And get at least 30 minutes a day 5 days a week of moderate exercise or 75 minutes each week of vigorous exercise ( or a combinatio­n of moderate and vigorous activity), according to American Heart Associatio­n guidelines.

Though doctors disagree on specific targets for the so- called “lousy” cholestero­l, the lower the number, the better. Cholestero­l levels are measured in milligrams per deciliter of blood ( mg/ dL).

And even if you have high levels of the good guy — the “hero” or “helper” cholestero­l called HDL — no amount of boosting HDL has been shown to lower the risk, experts say.

The latest guidelines from the American College of Cardiology and the American Heart Associatio­n say that doctors and patients should collaborat­e on the best way to control bad cholestero­l, rather than focusing specific numerical targets. High- risk patients should take statins, research has concluded.

So who is most at risk? Studies show that African- Americans are at higher risk of heart attack than their white counterpar­ts with the same bad cholestero­l levels. The guidelines also identified three specific high- risk groups:

“The goal is to lower your risk with a good diet, regular exercise, stopping smoking and keeping your weight down,” said Dr. Neil J. Stone, the Robert Bonow professor of medicine at Northweste­rn University’s Feinberg School of Medicine.

“For people under age 40, lifestyle is crucial,” Stone said. It’s never too late, but people who cling to unhealthy patterns into their 60s may not be able to reverse the damage they’ve already done, he said. Guidelines fromthe American Associatio­n of Clinical Endocrinol­ogists ( AACE) and the American College of Endocrinol­ogy ( ACE), published in the April issue of Endocrine Practice recommend for the first time an LDL goal of less than 55 milligrams/ dL for people at “extreme risk” for heart disease; less than 70 for those with a “very high risk;” less than 100 for “high to moderate risk” people, and less than 130 for people at “low risk.”

While most people with heart disease have symptoms, some at increased risk, including many with diabetes, are unaware of their “silent” heart disease, said Paul S. Jellinger, the lead author of the 2017 AACE/ ACE Treatment of Lipid Disorders Guidelines and professor of clinical medicine at the University of Miami’s Miller School of Medicine.

“In all these individual­s, LDL cholestero­l should be lowered, regardless of where the LDL is to begin with,” he said.

Jellinger says people whose risk remains unclear after considerin­g the wellknown risk factors should ask their doctors to measure their coronary artery calcium score, a useful predictor of risk, to estimate the amount of plaque in their arteries.

People at a very high risk of a heart attack can take statins in combinatio­n with ezetimibe or with PCSK- 9 inhibitors, endocrinol­ogists say. The latter are powerful LDL cholestero­l- lowering drugs that regulate LDL receptors so they pull the bad cholestero­l out of your blood and put it back into your liver cells where it belongs.

But the PCSK- 9 inhibitors can cost be very expensive since insurance companies can make it difficult for people to get coverage to help pay for the drugs, Jellinger said.

“The key questions to ask your doctor, he said, are: ‘ What ismy risk? What ismy LDL level? And what LDL target should I aim for, based on my risk level?’”

Sandra Guy is a local freelance writer.

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 ?? | PROVIDED PHOTO ?? Dr. Jennifer Robinson, a professor in the college of public health at the University of Iowa, says, “Usually, age 50 is where people’s lifestyles or their genes are catching up with them.”
| PROVIDED PHOTO Dr. Jennifer Robinson, a professor in the college of public health at the University of Iowa, says, “Usually, age 50 is where people’s lifestyles or their genes are catching up with them.”
 ??  ?? Dr. Neil J. Stone
Dr. Neil J. Stone

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