Daily Freeman (Kingston, NY)

Surgery can lessen symptoms of condition

- Robert Ashley

What can be done for normal pressure hydrocepha­lus? My dad was diagnosed with this condition six months ago after developing severe gait problems, urinary urgency and memory issues. He has a few other physical issues, but is otherwise healthy.

I’m glad your father’s doctor was able to pinpoint the source of his symptoms. Because normal pressure hydrocepha­lus (NPH) is a rare condition, with a gradual onset of symptoms, it can be difficult to diagnose. The annual incidence is between 1.19 and 3.4 per 100,000 people. This form of hydrocepha­lus, or “water on the brain,” can occur after a head trauma, stroke or brain tumor, but in some cases, the cause is unknown. To understand the condition takes an understand­ing of the fluid that bathes the entire brain and that flows through its ventricles, or cavities.

This fluid, called cerebrospi­nal fluid, is produced by the lateral ventricles of the brain and is eventually reabsorbed into the body through veins within the brain. If the body has difficulty reabsorbin­g the fluid, the fluid increases within the ventricles, putting pressure on the brain itself. This pressure damages the nerves and nerve connection­s within the brain. Initial symptoms include difficulty walking, as if a person’s feet are glued to the floor, and with the feet outwardly rotated. Patients also have difficulty turning and can lose stability and fall.

People with the condition also have concentrat­ion problems, slowed mental abilities and a lack of concern for their disability. Lastly, they have urinary urgency, which can lead to urinary incontinen­ce.

Once you have a diagnosis, however, you can move to treatment, which consists of decreasing the level of cerebrospi­nal fluid within the skull.

This is done through a ventriculo­peritoneal (VP) shunt. After drilling a small hole in the skull, a neurosurge­on places a catheter into the lateral ventricle within the brain. That catheter is attached to a valve behind the ear. From the valve, another catheter is guided down the neck and into either the chest or abdomen. When the pressure builds in the ventricle, the valve opens, draining the fluid from the brain into the chest or abdomen, depending where the second catheter ends. This fluid is then reabsorbed by the body.

The effectiven­ess of shunts varies widely, studies suggest. The greatest patient improvemen­ts seem to be in the ability to get up out of a chair and walk. Memory and reaction time also can improve after shunting, as can urinary symptoms. However, if memory deficits are to the point of moderate to severe dementia, then a shunt may not help that aspect.

One important thing to note is that the longer the patient has symptoms, the less likely a shunt will provide benefit. This is especially true if symptoms have been present for more than two years.

VP shunts can have many complicati­ons, including a risk of bleeding, brain infections, seizures, malfunctio­n of the shunt or an over-drainage of cerebrospi­nal fluid. The rates of these complicati­ons are decreasing, but still can occur up to a third of the time.

Based on what you’ve told me, the cause of your father’s hydrocepha­lus is unclear. Nonetheles­s, if the shunt is stable, patients like your father can have sustained benefit for many years. CRYPTOQUOT­E

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