90% of tired women have this sneaky genetic glitch

Genetic testing is revealing that mutations of a key health regulating gene (MTHFR) are far more common than previously thought. “I see it in 90 percent of my patients,” says Stephanie Cave, M.D., who treats women with chronic fatigue. The concern: Those with the faulty gene can’t properly convert folic acid (a synthetic form of folate) into the active form needed for methylation—a biochemical process crucial to the function of nearly every body system.

The gene mutation itself isn’t new, but women today feel the negative effects more than past generations. Why? In 1998 the FDA mandated that all processed grains be fortified with folic acid, so we now consume far more of the synthetic vitamin than our grandmothers did. People with the genetic glitch (who already face an energy crisis due to poor methylation) can’t process the high levels of folic acid and risk a toxic buildup that further saps well-being.

An MD blood test or at-home saliva test from a DNA testing company can ID the mutation (for around $100). Even if tests show no mutation, consider the steps below. “You don’t have to have a mutation for your MTHFR gene to not work well,” says Ben Lynch, N.D., author of Dirty Genes. “Many women over 40 struggle with faulty genes due to environmental or hormonal issues.”

Dietary tweaks to support the gene are 100 percent effective, says Lynch. Avoid food fortified with folic acid and up your intake of natural folate, which helps prevent fatigue, depression, cancer and birth defects (key for women who may become pregnant). Top sources: beans, raw leafy greens, liver.

Pick a multi with methylated folate, which the body can process even with the genetic glitch. Try: Life Extension Two-Per-Day (LEF.com/ffw).