Leptin resistance triggering a new epidemic of fatigue

“Virtually all women have some degree of leptin resistance,” asserts metabolic medicine specialist Ron Rosedale, M.D. The hormone tells the brain you’re full, controls energy and plays a key role in regulating heart rate, stress response, metabolism and more. “Leptin is the body’s most powerful regulator,” he says. But when you have too much, your body doesn’t hear its messages. The result? Leptin resistance. “It’s like a car alarm,” says neurologist Joseph Oommen, M.D. “The first 10 seconds, everybody looks. But once you know there’s no burglar, you treat the signal like noise. That’s what the body does when a hormone is elevated for a long period.”

A high-sugar/high-carb diet raises leptin levels, says Dr. Oommen. But most doctors won’t link the vague symptoms (fatigue, fog, headaches) to impaired leptin signaling, says Dr. Rosedale.

A blood test can measure leptin, but the results can be tough to interpret, says Dr. Rosedale. If you have excess belly fat and carb cravings, you likely have high leptin, and the steps below can help.

Try diet tweaks. Limiting protein to 50 to 60 grams a day and eating healthy fats (nuts, seeds, avocado, eggs, grass-fed meat and wild-caught fish) can help, says Dr. Rosedale. “Besides water, fats are the only thing we consume that don’t raise leptin.” Also key: cutting sugar and starchy carbs that turn to sugar, like potatoes and pasta, for three weeks, then adding them back slowly if doing so doesn’t cause cravings.

Take a soak. Adding lavender essential oil to a bedtime bath calms the central nervous system to fight stress and sleeplessness, both of which raise leptin. What’s more, studies show that when skin absorbs the oil, its active compounds reduce leptinraising oxidative stress in the body.