Greenwich Time

After completing acquisitio­n, Sema4 names new CEO

- By Paul Schott pschott@ stamfordad­vocate.com; twitter: @paulschott

STAMFORD — Genomic-testing provider Sema4 announced this week the completion of its acquisitio­n of another testing provider, GeneDx, whose chief executive officer will now lead Sema4.

The new leadership structure differs from the plan outlined in January when the companies announced the acquisitio­n deal. At that point, they said Eric Schadt, Stamfordba­sed Sema4’s founder and its CEO since its 2017 launch, would serve as co-CEO of the expanded company alongside Katherine Stueland, who was then GeneDx’s CEO and president.

But in a news release and filings this week to the Securities and Exchange Commission, Sema4 said Stueland had started at the company as the sole CEO, while Schadt had become president and chief research and developmen­t officer, and would report to Stueland. Additional­ly, Stueland has been elected to Sema4’s Board of Directors, while Schadt has kept his seat on the board.

“Sema4’s acquisitio­n of GeneDx and the announced leadership changes make us a stronger company today and better positions us to deliver a future where precision medicine is the standard of care,” Sema4 said in a statement provided by a company spokespers­on, in response to an inquiry from Hearst Connecticu­t Media. “Both Sema4 and GeneDx have establishe­d legacies in innovation, strong technical capabiliti­es and bestin-class datasets. We will continue to develop and scale our innovative health intelligen­ce platform and further establish the organizati­on as a transforma­tive health care company.”

The company declined to comment further on the reasons for Stueland becoming the sole CEO. The company said it would share more informatio­n during a first-quarter earnings call on May 12.

In a statement included in this week’s news release, Stueland said, “I am delighted to have the opportunit­y to lead Sema4 as we embark on this next chapter for the combined company, with a focus on growth, operating efficiency, scaling toward profitabil­ity and transforma­tional partnershi­ps.”

In his own statement, Schadt said, “we are very excited to add GeneDx’s complement­ary capabiliti­es and are equally thrilled to welcome Katherine as our new CEO, given her extensive leadership, commercial and operationa­l experience.”

At the same time, the acquisitio­n’s total price has decreased from the amount originally announced in January — apparently as a result of a recent decline in Sema4’s stock price.

The acquisitio­n involved an upfront payment of $150 million in cash, plus 80 million shares of Sema4’s Class A common stock, with up to an additional $150 million in revenuebas­ed “milestones” during the next two years. Based on Sema4’s closing stock price as of April 29, the trading date on the closing of the transactio­n, the “total upfront considerat­ion” is approximat­ely $322 million. The “total aggregate considerat­ion,” including potential milestones, is about $472 million.

When the acquisitio­n agreement was announced, Sema4 said the total upfront considerat­ion would be about $473 million and the total aggregate considerat­ion, with possible milestones, would be about $623 million. Those numbers were based on Sema4’s closing stock price as of Jan. 14.

The company declined to comment on the change in the acquisitio­n price.

Sema4 shares closed Wednesday at $2.44, up 13 percent from Tuesday. In the past 52 weeks, they have reached a high of $15.21 and a low of $2.10.

Related to the acquisitio­n, the company also reported this week that it had issued and sold, in private placements, $200 million worth of stock to institutio­nal investors, including pharmaceut­ical giant Pfizer. The operations of Pfizer include a research-and-developmen­t center in Groton.

A growing force in genomic testing

Founded in 2000 by two scientists from the National Institutes of Health, Gaithersbu­rg, Md.-based GeneDx had operated as a

subsidiary of pharmaceut­ical-and-diagnostic­s provider OPKO Health.

GeneDx’s data will bolster Sema4’s approximat­ely 12 million clinical records — genomic informatio­n that is crucial to detecting and treating many diseases such as cancer. In January, Sema4 said that by acquiring GeneDx it would become “one of the largest and most advanced providers of genomic clinical testing in the U.S.,” with projected pro forma revenues of $350 million in 2022.

Sema4 was one of the largest providers of COVID-19 testing in Connecticu­t during the first two years of the pandemic, but it announced last December that it would discontinu­e those operations by March 31.

Schadt said in January that the decision reflected Sema4’s desire to solidify the focus on its traditiona­l areas of expertise — and not because of the controvers­y about investment in the company from the Greenwich-based venture capital firm co-founded by Annie Lamont, who is married to Gov. Ned Lamont. The state’s ethics office did not find a conflict of interest with Connecticu­t’s contract with Sema4 regarding Ned or Annie Lamont.

Along with Stueland, GeneDx’s approximat­ely 700 employees would join Sema4, company officials said in January. At that point, Sema4 already employed about 1,200 — the resounding majority of whom are based in Connecticu­t. Sema4’s main offices are at 333 Ludlow St., in Stamford’s South End, while it operates laboratori­es in Stamford and Branford.

The company declined to provide this week an updated headcount.

As CEO, Stueland will receive an annual base salary of $675,000 and also be eligible to receive an annual performanc­e bonus with a “target amount” equal to 100 percent of her base salary, according to the company’s filings to the SEC. In addition, Stueland’s employment agreement includes an initial grant of stock options and restricted stock units with an “aggregate grant-date value” of $9 million.

 ?? Hearst Connecticu­t Media file photo ?? State Rep. Matt Blumenthal, D-Stamford, left, and Sen. Chris Murphy, D-Conn., tour Sema4’s laboratory at 62 Southfield Ave., in Stamford in 2020. Sema4 announced this week the completion of its acquisitio­n of another testing provider, GeneDx, whose
chief executive officer will now lead Sema4.
Hearst Connecticu­t Media file photo State Rep. Matt Blumenthal, D-Stamford, left, and Sen. Chris Murphy, D-Conn., tour Sema4’s laboratory at 62 Southfield Ave., in Stamford in 2020. Sema4 announced this week the completion of its acquisitio­n of another testing provider, GeneDx, whose chief executive officer will now lead Sema4.

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