Houston Chronicle Sunday

Sugar, salt— nomicrochi­ps — are ingredient­s in vaccine

- By Katherine J. Wu

There are 10 ingredient­s in Pfizer’s coronaviru­s vaccines. Contrary to several conspiracy theories circulatin­g online, a tracking microchip planted by the government to surveil the movements of Americans is not among them.

For months, widely shared videos and viral posts on social media have baselessly claimed that such technologi­es could find their way into syringes delivering shots. None of the rumors is true.

With millions of doses of Pfizer’s newly authorized vaccine getting distribute­d nationwide, the rumors have resurfaced, prompting the pharmaceut­ical company to publicize what actually is in its immunizing recipe.

In the vaccine itself, there’s one active ingredient: a molecule called messenger RNA, or mRNA, which contains genetic instructio­ns for a coronaviru­s protein called spike. Once injected, the mRNA will instruct human cells to manufactur­e spike, exposing the immune system to a highly recognize feature of the virus. The idea is to help the body learn one of the virus’ most distinguis­hing traits so the virus will be recognized and rapidly quashed if it tries to establish an infection.

The mRNA rapidly degrades, leaving no trace in the body. All that’s left behind is a molecular memory of the virus — the intended goal of any vaccine.

Pfizer’s vaccine also contains nine other ingredient­s. Four of them are lipids with impossibly complex chemical names: (4-hydroxybut­yl) azanediyl) bis(hexane-6,1-diyl) (ALC-3015); (2- hexyldecan­oate),2-[(polyethyle­ne glycol)-2000]-N,N-ditetradec­ylacetamid­e (ALC-0159); 1,2-distearoyl­snglycero(DPSC); and cholestero­l.

These lipids come together to form a greasy, protective bubble around the mRNA, which is naturally very fragile and would be chopped to bits if injected directly into the body. Swaddled in an oily sphere, the genetic instructio­ns have a better shot of finding their way into cells.

The vaccine also includes sucrose, or sugar, which keeps the nanopartic­les from clumping up when they’re frozen in storage.

The vaccine also contains four salts: potassium chloride, monobasic potassium phosphate, basic sodium phosphate dihydrate and sodium chloride. If that last ingredient looks familiar, it should: It’s table salt.

These common chemicals are found in a variety of treatments and vaccines that have long been in use. The salts in the vaccine help match its contents to the environmen­t of the human body, which contains its own mix of natural salts.

Jerica Pitts, Pfizer’s director of global media relations, also notes that the vaccine is diluted with water and salt before injection, another step to ensure that the balance of salts in the mix is just right.

None of these ingredient­s contains or resembles microchips.

 ?? Jack Guez / AFP via Getty Images ?? Social media videos have baselessly said government microchips could go into coronaviru­s vaccines.
Jack Guez / AFP via Getty Images Social media videos have baselessly said government microchips could go into coronaviru­s vaccines.

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