Houston Chronicle

Daily aspirin regimen doesn’t work for everyone.

- JOE AND TERESA GRAEDON Write to Joe and Teresa Graedon via their website: peoplespha­rmacy.com.

People’s Pharmacy:

Q: A friend of mine, a woman in her 50s, collapsed on the street in Canada with internal bleeding. She is alive today only because she was in a big city with quick responders and not out on her boat at sea.

The cause was the baby aspirin she was taking every day on her doctor’s advice. Even though aspirin may have benefits, it is a mistake to overlook its serious risks.

A: No one really understand­s why some people can tolerate large doses of aspirin without noticing problems while others may suffer potentiall­y life-threatenin­g bleeding ulcers on a very modest dose of this drug.

In the 1970s, doctors were advised to prescribe as much as 6,000 mg of salicylate daily (18 aspirin tablets) for rheumatoid arthritis (The Pharmacolo­gical Basis of Therapeuti­cs, Fourth Edition). But even a daily baby aspirin (81 mg) can lead to serious consequenc­es such as your friend experience­d. That is why no one should take aspirin on a regular basis without medical supervisio­n.

Q: Using beets to increase nitric oxide in the blood for 24 hours before using Viagra will make the little blue pill work better. Eating beets or drinking beet juice a couple of times the day before the event makes a huge difference.

We went from giving up because even a pump didn’t help to “oh, my word!” if you get my drift. My husband also takes L-citrulline and L-arginine that same day for an extra boost, but the key is the beet juice. We are in our late 70s.

You can buy beet juice at any naturalfoo­d store. Even if the ED pills don’t seem to work for you, this could make a big difference. It might even give you natural performanc­e back if you drink beet juice daily. It takes a couple of months to build up the nitric oxide in the bloodstrea­m to the point of having really good results, but it is worth the effort.

A: Thank you for your intriguing suggestion. Sildenafil (Viagra) and tadalafil (Cialis) work by blocking an enzyme (PDE5) that breaks down a compound called cGMP. Nitric oxide also leads to higher levels of cGMP. This dilates blood vessels in the penis and facilitate­s increased blood flow.

Foods like beets or dark chocolate also enhance nitric-oxide formation. Studies have found that beet juice improves flexibilit­y of the lining of blood vessels and lowers blood pressure (Nutrients, April 2015).

Although there are no studies to suggest that beets or juice can improve the effectiven­ess of sildenafil, your personal experiment­s are fascinatin­g. One small study evaluated a formulatio­n containing Pycnogenol, Larginine and L-citrulline and found it seemed to work better than placebo for erectile dysfunctio­n (Minerva Urologica e Nefrologic­a, March 2015).

Q: Could you please comment about the news report a few months ago pertaining to calcium supplement­s? The study showed that calcium did not help older people’s bones and that it could actually be harmful, with side effects like heart attacks.

Now I am afraid to take my 1,500 mg of calcium with vitamin D per day and have cut the dose down to 500 mg of calcium a day. Am I doing the right thing? I am female, age 73.

A: You have mentioned a source of great confusion for many people. For years, doctors have been urging older people (especially women) to take high doses of calcium (1,200 mg/day) to prevent bone loss and avoid fractures.

The only problem with that recommenda­tion is that it was based on theory. When scientists reviewed studies of calcium intake and the risk of bone fracture, they found no associatio­n between the two. They concluded that “there is no clinical trial evidence that increasing calcium intake from dietary sources prevents fractures. Evidence that calcium supplement­s prevent fractures is weak and inconsiste­nt.” (BMJ online, Sept. 29, 2015).

Calcium supplement­s have some downsides. Too much calcium can increase the chance of kidney stones (New England Journal of Medicine, Feb. 16, 2006). In addition, people who take calcium supplement­s are at a greater risk of heart attack (BMJ online, July 29, 2010).

 ?? Charles Bertram / Lexington Herald-Leader / MCT ?? Some people are able to tolerate large doses of aspirin, while others can have a bad reaction to even small dosages.
Charles Bertram / Lexington Herald-Leader / MCT Some people are able to tolerate large doses of aspirin, while others can have a bad reaction to even small dosages.
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