Houston Chronicle

Funding uncertaint­y threatens addiction research

- By Sanjeev Khatiwada Sanjeev Khatiwada is a candidate for a doctorate at Baylor College of Medicine in Houston. He conducts his research in the Laboratory of Dr. Mauro Costa-Mattioli within the Memory and Brain Research Center, focusing on identifyin­g ri

As the U.S. grapples with the devastatin­g effects of the opioid epidemic, the nation has been forced into a deeper conversati­on about drug addiction and its causes. While we continue to debate solutions, the science is clear: Drug addiction is a disease, and scientists, lawmakers, and the public must come together in support of robust funding for biomedical research to combat this disease.

As a Ph.D candidate at Baylor College of Medicine, my research seeks to develop a deeper understand­ing of the brain, including identifyin­g risk factors that make some individual­s more susceptibl­e than others to the effects of addictive drugs. These advancemen­ts, which will assist in the developmen­t of novel therapeuti­c approaches to prevent drug addiction, are contingent upon robust federal funding of keystone agencies, including the National Institutes of Health (NIH) and the National Science Foundation (NSF).

Recognizin­g the critical importance of supporting scientific research, Congress has expressed opposition to the substantia­l cuts to NIH and NSF proposed in the president’s fiscal year 2018 budget. Although House lawmakers are showing support for NIH in their draft funding bill, they have proposed cuts to NSF. Any cuts to research would have widespread repercussi­ons, including delayed progress toward life-saving medical advancemen­ts.

With support from NIH, our lab has identified a molecular process that explains why adolescent­s are more vulnerable to the effects of addictive drugs. We have also pinpointed a genetic variation in the same molecular process that alters the effects of naturally rewarding substances, suggesting that genetic predisposi­tion is a risk factor for drug addiction. In addition to supporting discoverie­s like these, federal funding of biomedical research benefits our local and national economy.

In FY 2016 alone, NIH awarded Texas institutio­ns nearly $1.1 billion, directly supporting 23,442 jobs and bringing $3.7 billion in economic activity to our state — a return on investment of well over 200 percent. These investment­s have also contribute­d to the thousands of bioscience industries in our state, which employ more than 75,000 Texans.

Inconsiste­nt and insufficie­nt federal funding for biomedical research will also have a devastatin­g impact on the future of scientific research in this country. Without adequate funding, young scientists like myself will not have the same opportunit­ies as our predecesso­rs to conduct rigorous, high-quality research, and the field will not be able to retain its best and brightest young scientists. This squanders years of public investment in our training and robs our country of talent that could help us find treatments for the most devastatin­g diseases. Without a new generation of skilled scientists, treatment for the more than 20 million Americans suffering from addiction will remain insufficie­nt.

Investment­s made today will help develop more effective approaches to drug addiction, improving lives and reducing the more than $740 billion spent annually on costs related to crime, lost work productivi­ty and health care.

As a society, we must engage in thoughtful conversati­ons about the importance of federal funding for scientific research to ensure that America remains at the cutting edge of medical advancemen­t.

I urge U.S. Sens. John Cornyn and Ted Cruz, as well as U.S. Rep. John Culberson, to increase funding for scientific research and give hope to those struggling with life-threatenin­g and debilitati­ng diseases.”

 ?? Fotolia ?? Investment­s made today will help develop more effective approaches to drug addiction, improving lives and reducing the related costs.
Fotolia Investment­s made today will help develop more effective approaches to drug addiction, improving lives and reducing the related costs.

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