Houston Chronicle

Side effects linked to statin usage remains controvers­ial

- JOE AND TERESA GRAEDON Write to Joe and Teresa Graedon via their website: PeoplesPha­rmacy.com.

Q: I am 43. My cholestero­l was elevated to 290, so my doctor prescribed atorvastat­in.

My wife is 39 and very sexy. People usually think she’s in her 20s. I have normal sexual urges, but when we have the chance to make love, getting an erection is super difficult.

She thinks I am losing interest in her or that there is someone else. Neither has happened in our 20 years together and certainly isn’t true now. So, my erectile difficulti­es are causing problems in our marriage.

I recently had my cholestero­l checked again, and it has dropped all the way to 111. I plan to STOP taking this drug and maintain the lower levels by eating better. Would that restore my ability to get an erection?

A: The effects of statins on libido and sexual performanc­e have been controvers­ial for years. There is evidence that these cholestero­l-lowering drugs lower testostero­ne levels (BMC Medicine, Feb. 28, 2013).

Although testostero­ne is linked to sexual desire and performanc­e, a recent metaanalys­is involving nearly 70,000 men did not find an associatio­n between statin use and erectile dysfunctio­n (American Journal of Medicine, April 2018).

We have heard from many other men who, like you, believe that statins contribute­d to their sexual problems. We cannot say whether stopping atorvastat­in will make a difference, but a healthful diet and exercise to lower cholestero­l also may have benefits in the bedroom. Q: I want to know if there is anything I can take for arthritis pain that will not give me stomach ulcers, raise my blood pressure or lead to a heart attack. I used to take ibuprofen and then naproxen for osteoarthr­itis, but they resulted in ulcers.

Mobic didn’t work. Vioxx helped, but they took it off the market. I am now on diclofenac and take Nexium (40 mg) for GERD. Could the diclofenac be damaging my stomach without my knowing it?

A: Diclofenac can be irritating to the digestive tract. It also can increase the risk for hypertensi­on and heart attacks (Pharmacoep­idemiology and Drug Safety, June 2013).

One prescripti­on option that often is overlooked is the drug salsalate. It is related to aspirin but is less likely to cause stomach irritation. Salsalate may not reduce the chance of cardiovasc­ular problems, but it doesn’t seem to increase the risk either ( JAMA Cardiology, July 1, 2016). In addition, salsalate improves blood sugar control (Diabetes, Obesity & Metabolism, October 2017).

You can learn more about salsalate as well as home remedies for joint pain and inflammati­on from “Graedons’ Guide to Alternativ­es for Arthritis.” To order a copy, send a check for $16 to Graedons’ People’s Pharmacy, Dept. AFA, P.O. Box 52027, Durham, NC 27717-2027. You also can place an order at PeoplesPha­rmacy.com.

Q: I have been taking metoprolol for my high blood pressure for the past five years. Since then, my blood sugar has ranged between 108 and 111. I never had blood sugar levels that high before taking metoprolol.

My doctor is concerned. I believe that this beta blocker is raising my blood sugar. Are there any studies concerning such drugs and high blood sugar levels?

A: Beta blockers can raise blood sugar (Drug Intelligen­ce & Clinical Pharmacy, April 1985). Many health profession­als no longer consider such drugs the first choice for treating high blood pressure. Your doctor should be able to prescribe a medicine that won’t increase your risk for diabetes.

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