Houston Chronicle

Understand­ing the science behind hiccup remedies.

- JOE AND THERESA GRAEDON Write to Joe and Teresa Graedon via their website: PeoplesPha­rmacy.com.

Q: I’ve suffered with hiccups all my life (I’m in my late 50s). The only remedy that really works is one I learned from a friend about six years ago: Raise your left arm straight over your head while drinking a glass of water.

Can you tell me why this works? I’m guessing it has to do with the stretching motion expanding or opening up the diaphragm.

A: Hiccups are heard when the diaphragm repeatedly contracts involuntar­ily and the vocal cords close immediatel­y after each contractio­n. There are many triggers, including a large meal, hot peppers, alcohol, carbonated beverages and anesthesia. A number of serious health conditions also can set off hard-to-treat hiccups. That’s why persistent hiccups (beyond two days) should be brought to a doctor’s attention.

We have been collecting hiccup remedies for over 40 years. We suspect that many work by stimulatin­g nerves in the mouth and throat. This in turn might interrupt the muscular contractio­n. Raising the left arm while drinking water may help stimulate the vagus nerve, much as swallowing a spoonful of sugar would. This is a time-honored remedy for hiccups (New England Journal of Medicine, Dec. 23, 1971).

Other remedies, such as sipping pickle juice or eating olives, might work by activating transient receptor potential (TRP) channels in this same pathway. You can learn about many other hiccup remedies in our book “Quick & Handy Home Remedies.” It is available at PeoplesPha­rmacy.com.

Q: People with frequent migraine headaches often are advised to follow an eliminatio­n diet. Is there any evidence regarding its effectiven­ess?

A: A comprehens­ive review of diet and headache in the journal Headache (October 2016) notes that this is a controvers­ial topic. The research is not as rigorous as one might wish.

Foods that are thought to trigger migraines include alcoholic beverages like red wine, chocolate, coffee, aged cheese, nuts, processed meats such as salami, citrus fruits and milk. MSG (monosodium glutamate), caffeine and artificial sweeteners also have been implicated.

A small, randomized, controlled trial found that patients had fewer headaches and less pain during the eliminatio­n diet phase ( Journal of Headache Pain, Oct. 23, 2014).

Better research would be welcome. People who suffer migraines may want to do their own experiment­ation to see if eliminatin­g specific foods is helpful.

Q: I’ve found that a couple of slices of ripe papaya calms heartburn. It also provides a little fresh fruit to the diet. Papaya enzyme tablets work, but the fresh papaya is a better choice for me.

A: A doctor first reported the benefits of papain, an enzyme from papaya fruit, for treating heartburn in The British Medical Journal on April 3, 1886. Sadly, there has been very little well-controlled research over the subsequent decades.

As long as people are not allergic to papaya, your remedy is worth a try. Some people with latex allergy also are sensitive to papaya, mango, banana and avocado (Allergy, April 1997).

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