Houston Chronicle

SALIH JAWAD WAKIL. PHD

1927-2019

- Please visit Dr. Wakil’s online memorial tribute at geohlewis.com where words of comfort and condolence may be shared electronic­ally with his family.

Salih Jawad Wakil PhD, a renowned scientist whose contributi­ons in the field of fatty acid synthesis establishe­d the basis of our current understand­ing of this vital biologic process, died on Thursday, the 11th of July 2019, in Houston. He was 91 years of age.

Born the son of a shoemaker in Karbala, Iraq in 1927, Dr. Wakil read Charles Darwin’s “On the Origin of Species” in high school, which inspired him to dedicate his life to science. His placement as one of the top five students on the national baccalaure­ate exam of Iraq earned him a scholarshi­p to the American University of Beirut, where he completed his undergradu­ate degree in chemistry in 1948. He completed his PhD in biochemist­ry at the University of Washington, Seattle in 3.5 years. Dr. Wakil’s distinguis­hed career in fatty acid metabolism truly began when he became a Research Associate at the Institute for Enzyme Research at the University of Wisconsin at Madison. There he identified the separate pathway of fatty acid synthesis, which was counter to the leading premise at the time. He subsequent­ly discovered the two major enzymes of the pathway, Acetyl-CoA Carboxylas­e and Fatty Acid Synthase, and many other landmark discoverie­s during a scientific career spanning over 60 years.

During the 1960s, Dr. Wakil continued his work as a professor at Duke University in Durham, North Carolina. In 1971, Dr. Michael E. DeBakey personally recruited him to become the Chairman of the Verna and Marrs McLean Department of Biochemist­ry at Baylor College of Medicine in Houston. Dr. Wakil founded the distinguis­hed Verna and Marrs McLean Annual Lecture Series, which is currently in its 48th year and has hosted over 35 Nobel Laureates and other leading scientists to present their groundbrea­king work to the Baylor College of Medicine community. At Baylor, he went to great efforts and took great pride in supporting

the faculty, students and growing the Department of Biochemist­ry into one of the leading research programs in the country.

In 2010, Dr. Wakil, along with his collaborat­ors, Dr. Motonari Uesugi and Dr. Lutfi Abu-Elheiga, founded FGH BioTech, Inc. in Houston to develop novel technology regulating fat and energy metabolism. The culminatio­n of Dr. Wakil’s discoverie­s in the laboratory has great potential to yield beneficial therapies for cancer, cardiovasc­ular disease, diabetes, and obesity. More recently, Dr. Wakil served as Chairman Emeritus of Biochemist­ry at Baylor College of Medicine and Chairman of the Board at FGH BioTech.

Dr. Wakil’s career achievemen­ts earned him a 1990 election into the National Academy of Sciences. Additional awards and honors include: Bristol Meyers Squib Metabolic Research Award, the Paul Lewis Award in Enzyme Chemistry (the Pfizer Award), the Distinguis­hed Duke Alumnus Award, the Chilton Award from University of Texas Southweste­rn Medical Center, the Kuwait Prize, election to fellowship

in the American Academy of Microbiolo­gy, the Supelco/American Oil Chemists’ Society Research Award, the Yamanouchi USA Foundation Award, and his personal favorite, Admiral in the State of Texas Navy.

Dr. Wakil leaves a legacy of love for his family, friends and colleagues whose lives he touched both personally and profession­ally. Salih and his wife, Fawzia, hosted many gatherings, opening their home to guests from around the world with gracious hospitalit­y and warm friendship. His generosity of time, care and assistance to others has impacted many lives. He will be dearly missed.

Dr. Wakil spent his free time traveling, fishing, and exercising at the Houstonian, often ending his days with a nice glass of wine. One of his finest achievemen­ts was seeing the bestowal of medical degrees on his four children. Dr. Salih J. Wakil is survived by his wife of 66 years, Fawzia; his four children, Sonya, Aida, Adil, and Joe, their spouses; seven grandchild­ren; and many nieces and nephews.

Friends are cordially invited to a visitation with the family from five o’clock in the afternoon until eight o’clock in the evening on Thursday, the 18th of July, in the library and grand foyer of Geo. H. Lewis & Sons, 1010 Bering Drive in Houston.

At a later date, the family will gather for a private interment at Glenwood Cemetery in Houston.

In lieu of customary remembranc­es, the family requests with gratitude that memorial contributi­ons in his name be directed to Baylor College of Medicine and mailed to the Salih J. Wakil Memorial Fund for student support at the Department of Biochemist­ry, c/o Office of Institutio­nal Advancemen­t, MSC #800, P.O. Box 4976, Houston, TX 77210. Secure online gifts may be made by credit card at www.bcm.edu/ giving.

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