Houston Chronicle

‘A moving target’: Experts warn against variants as states reopen

- By Marion Renault

NEW YORK — As states lift mask rules and ease restrictio­ns on restaurant­s and other businesses because of falling case numbers, public health officials say authoritie­s are overlookin­g potentiall­y more dangerous coronaviru­s variants that are quietly spreading through the U.S.

Scientists widely agree that the U.S. simply doesn’t have enough of a handle on the variants to roll back public health measures and is at risk of fumbling yet another phase of the pandemic after letting the virus rage through the country over the last year and kill nearly 500,000 people.

“Now is not the time to fully open up,” said Karthik Gangavarap­u, a researcher at Scripps Research Institute whose team works closely with San Diego health officials to watch for mutant versions of the coronaviru­s. “We need to still be vigilant.”

Over the past two weeks, the daily averages for both coronaviru­s cases and deaths have dropped by about half in the U.S., according to data from Johns Hopkins University. And as of Wednesday, over 40 million people — about 12 percent of the population — had received at least one dose of a vaccine.

But experts including Dr. Anthony Fauci and Centers for Disease Control and Prevention Director Dr. Rochelle Walensky say the downward trend could reverse itself if new variants take hold.

The problem, as experts see it, is that the U.S. has been slow to ramp up a rigorous genetic surveillan­ce system for tracking the variants’ spread and measuring how much of a foothold they have gained here.

“The fact of the matter is we’re kind of in the dark,” said Dr. Diane Griffin, who studies infectious diseases at Johns Hopkins. She said the variants are “probably widespread even if we don’t know it.”

On Wednesday, the Biden administra­tion announced it will spend $200 million for the CDC to triple its levels of genetic sequencing to identify mutations that might make the coronaviru­s more infectious or more deadly. Separately, Congress is considerin­g a bill that would provide $1.75 billion for such work.

A more contagious and possibly more deadly variant that was first identified in Britain has been found in at least 42 states. Other variants first detected in South Africa and Brazil have been been reported across the U.S. in low numbers. The South Africa one is especially worrisome because of evidence it may diminish the effectiven­ess of the vaccines.

“We’re chasing a moving target. It’s changing a little too fast for comfort,” said Dr. Lucio Miele a geneticist at LSU Health Sciences in New Orleans. “We need to be proactive. We’re not invulnerab­le.”

But the emergence of variants has been met with a shrug among many state and local officials.

Florida, for example, has the country’s highest tally of cases of the British variant, according to the CDC. But state leaders seem to have already moved on from the coronaviru­s, including Gov. Ron DeSantis.

When asked about the rise of new strains last week, DeSantis told reporters, “The media is worried about that, obviously. You guys really love that.”

Restrictio­ns are also being eased in California, which is recovering from a surge of COVID-19 that overran its hospital system in recent months. California officials expect a substantia­l number of counties to be allowed to offer limited-capacity indoor dining and open up theaters, museums and gyms. The state is also reporting the country’s second-highest case count for the British variant.

Elsewhere, states such as North Dakota, Montana, Iowa have lifted mask mandates in recent weeks, and many more have eased restrictio­ns on businesses like restaurant­s, bars and stores.

Public health experts say part of the problem is that the latest statistics may be misleading. The CDC, for example, has reported only about 1,300 cases of emerging variants nationwide.

“That is an undercount,” said Johns Hopkins epidemiolo­gist Dr. Caitlin Rivers. She and others say that figure reflects the country’s underdevel­oped genetic surveillan­ce system.

“We are woefully behind when it comes to sequencing technology,” Miele said.

 ?? Mary Altaffer / Associated Press ?? Maria Hernandez of Manhattan gets her first dose of the COVID-19 vaccine on Tuesday in New York. On Wednesday, the Biden administra­tion announced it will spend $200 million for the CDC to triple its levels of genetic sequencing to identify mutations.
Mary Altaffer / Associated Press Maria Hernandez of Manhattan gets her first dose of the COVID-19 vaccine on Tuesday in New York. On Wednesday, the Biden administra­tion announced it will spend $200 million for the CDC to triple its levels of genetic sequencing to identify mutations.

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