Houston Chronicle

‘Frugal design’ spurs medical innovation­s

- By Rebecca Richards-Kortum and Theresa Mkandawire Richards-Kortum is a professor of bioenginee­ring at Rice University. Mkandawire is an associate professor of civil engineerin­g at the University of Malawi. This piece was published in The Conversati­on.

Dr. Msandeni Chiume Kayuni found herself in the middle of a supply crisis as COVID-19 spread to Africa in April 2020. As head of pediatrics at Kamuzu Central Hospital in Lilongwe, Malawi, her team faced a critical shortage of N95 and regular surgical face masks. Nurses and doctors were striking.

“We had members of hospital staff put their tools down because they did not feel it was safe to practice,” she told us in an interview.

Ingenuity kicked in. The Malawi team purchased raincoats from the local market to use as personal protective equipment when they could not afford appropriat­e gowns that cost three times as much. Unlike disposable gowns, the rain gear could easily be sanitized in bleach and reused.

Worldwide, as the global supply chain for basic PPE, diagnostic tests and equipment to treat critically ill COVID-19 patients buckled under the strain, medical personnel improvised and engineers began developing solutions almost overnight. Engineerin­g students used university-based makerspace­s to invent and produce new technologi­es — face shields, automated handwashin­g stations, diagnostic testing equipment and respirator­y support equipment — that allowed health care workers to safely deliver effective care.

As engineers working in the U.S. and Malawi to develop effective and affordable medical devices for low-resource communitie­s, we routinely practice and teach this level of resourcefu­lness, dubbed “frugal design.”

Spreading the light

Medical personnel reused available N95 masks, intended to be used once, for weeks or months, which required innovative ways to disinfect them, including heaters, gas sterilizer­s and ultraviole­t light.

UVC — short-wavelength ultraviole­t light — kills or inactivate­s viruses, including SARS-CoV-2, the virus that causes COVID-19. In the pandemic, scientists set up UVC systems in spare rooms at hospitals to sanitize masks.

The University of Nebraska Medical Center equipped a room with UVC light towers and coated the walls with reflective foil to maximize the dose of UVC light. Dirty masks are clipped to rows of clotheslin­e strung across the UVC room. An operator outside the room started the lights, and a detector in the room ensured the masks had received a virus-killing dose of light. Masks can be disinfecte­d and reused multiple times without damaging their integrity.

Engineers in Houston, Malawi and Tanzania worked together to reduce the cost of room-based UVC disinfecti­on systems to less than $800, and several systems are now installed in hospitals in Malawi and Tanzania. Engineers at other locations built disinfecti­ng stations by adapting UV lights in the hoods normally used to grow cells in culture or by repurposin­g the UV light in an aquarium sanitizer.

Local innovation for PPE

Across the world, engineerin­g students used novel makerspace­s at universiti­es with 3D printers and laser cutters to rush new PPE designs into large-scale local production. Students and staff at Malawi’s two engineerin­g schools, Malawi Polytechni­c

and the Malawi University of Science and Technology, and at Tanzania’s Dar es Salaam Institute of Technology, adapted open-source designs to produce face shields. They consulted with clinicians at partner hospitals to improve comfort and safety while using only locally available materials.

Developmen­t organizati­ons, including UNICEF and the United Nations Developmen­t Program, ordered over 52,000 face shields that were locally produced and delivered to area hospitals.

Reinforcin­g ventilator supplies

In response to the global shortage of ventilator­s in the first months of the pandemic last year, engineers designed simple devices to provide temporary breathing support. Open-source plans for two systems, one designed by the MIT Emergency Ventilator Project and one designed by students and staff at Rice University, are available online.

A global shortage of oxygen in lowresourc­e countries has led many health care providers in those countries to fall back on mechanical ventilatio­n. Ventilator­s are also in short supply, in part because of problems with a U.S. ventilator donation program.

Students and faculty at the Malawi University of Science and Technology developed a system similar to the MIT and Rice ventilator­s that can be assembled using materials available in Malawi. Students at Malawi Polytechni­c worked with local physicians to develop a ventilator with more features.

Hygiene innovation

Public health officials emphasize the role of handwashin­g, together with social distancing and face masks, to curb the continued spread of COVID-19. However, many schools and even some hospitals in low-resource settings do not have running water and sinks allowing students and patients to regularly wash their hands.

In response, Brenald Dzonzi, an engineerin­g student at Malawi Polytechni­c, designed a no-touch hand-washing station. Small amounts of soap and water are automatica­lly dispensed from pre-filled containers when a user stands in front of the station. The system is made from local materials and is now installed at a local hospital. Up to 2,000 patients can safely wash their hands before the system needs to be refilled.

Dzonzi was awarded the UNICEF Youth Challenge award to fund continued developmen­t of the handwashin­g station.

When equipment is unsuitable for an environmen­t, because it can’t tolerate hot, dusty conditions, for example, it ends up discarded in equipment graveyards — serving no one. In contrast, successful­ly executed frugal designs offer sustainabi­lity and suitabilit­y for lowresourc­e environmen­ts.

Universiti­es across the world are changing how they teach engineerin­g — focusing on frugal design and engaging students like Dzonzi to invent solutions that solve real problems. Though the pandemic sparked a global need for frugal design, the practice is important for narrowing the health care gap between high- and low-resource communitie­s and bringing health care services to underserve­d areas.

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