Study supports a link between virus and MS
There’s more evidence that one of the world’s most common viruses may set some people on the path to developing multiple sclerosis.
Multiple sclerosis is a potentially disabling disease that occurs when immune system cells mistakenly attack the protective coating on nerve fibers, gradually eroding them.
The Epstein-Barr virus has long been suspected of playing a role in development of MS. It’s a connection that’s hard to prove because just about everybody gets infected with Epstein-Barr, usually as kids or young adults.
Thursday, Harvard researchers reported one of the largest studies yet to back the EpsteinBarr theory.
They tracked blood samples stored from more than 10 million people in the U.S. military and found the risk of MS increased 32-fold following Epstein-Barr infection.
The military regularly administers blood tests to its members and the researchers checked samples stored from 1993 to 2013.
Just 5.3 percent of recruits showed no sign of Epstein-Barr when they joined the military. The researchers compared 801 MS cases subsequently diagnosed over the 20-year period with 1,566 service members who never got MS.
Only one of the MS patients had no evidence of the EpsteinBarr virus prior to diagnosis.
The findings “strongly suggest” that Epstein-Barr infection is “a cause and not a consequence of MS,” study author Dr. Alberto Ascherio of the Harvard T.H. Chan School of Public Health and colleagues reported in the journal Science.
It’s clearly not the only factor, considering that about 90 percent of adults have antibodies showing they’ve had EpsteinBarr — while nearly 1 million people in the U.S. are living with MS, according to the National Multiple Sclerosis Society.
The virus appears to be “the initial trigger,” Drs. William H. Robinson and Lawrence Steinman of Stanford University wrote in an editorial accompanying Thursday’s study.
Epstein-Barr is best known for causing “mono,” or infectious mononucleosis, in teens and young adults but often occurs with no symptoms.