Imperial Valley Press

Cough syrup likely a factor in longtime alcoholic’s dementia

- KEITH ROACH, M.D. Dr. Roach regrets that he is unable to answer individual letters, but will incorporat­e them in the column whenever possible. Readers may email questions to ToYourGood­Health@med. cornell.edu or request an order form of available health ne

DEAR DR. ROACH: My 60-year-old husband is a longtime alcoholic. He is also bipolar. His current drug of choice is cough syrup.

He drinks a bottle a day or more of generic cough syrup without alcohol. At age 59, he was diagnosed with early dementia, which I attribute to the cough syrup abuse, as he doesn’t have the other risk factors of age or family history.

When he has abstained while in in-patient rehabs, his memory and cognition show marked improvemen­t.

He also takes daily thyroxine, lithium, duloxetine, high-dose gabapentin, trazodone, naproxen and famotidine.

He gave up alcohol in 1999, after 30-plus years of drinking, by his account. At that time and until a couple of years ago, he was abusing prescripti­on opioids and benzos (sedatives), along with cough syrup at some point.

He lost his access to the prescripti­ons, and now it’s only cough syrup.

The dementia symptoms began to appear after that point. He is following with a neurologis­t who has performed cognitive and memory testing, and said his condition is worsening.

I personally witnessed him unable to subtract 7 from 100. It’s sad and hard to watch.

There is very little research on the effects of cough syrup abuse, at least that I have been able to find. This may be partly due to the fact that it isn’t widely abused, and generally abusers are teenagers, not senior citizens.

Can you offer any insight on the cough syrup abuse effect on dementia? -- A.S.

ANSWER: Dextrometh­orphan, one of the active ingredient­s in most cough syrups, is well-described as a drug of abuse.

It indeed is most commonly used by teens and young adults, and there are medical issues in your husband that make this drug particular­ly dangerous for him, even potentiall­y life-threatenin­g.

DXM is safe and has no psychologi­cal effects when taken at the usual doses to suppress cough. However, when large amounts are taken (e.g., an entire bottle), the effects are dramatic and may resemble intoxicati­on with phencyclid­ine (PCP, or “angel dust”).

These may include hallucinat­ions and psychosis (a grossly distorted sense of reality). With chronic use, there are clear reports of progressiv­e cognitive deteriorat­ion, exactly as you describe.

DXM itself acts on the neurotrans­mitter serotonin, and when combined with certain other drugs -- including the duloxetine, gabapentin and trazodone -- can cause serotonin syndrome, which is potentiall­y fatal.

Symptoms of serotonin syndrome include muscle stiffness or twitching, fever and mental status changes, including anxiety, restlessne­ss and disorienta­tion.

The cough syrup is at least partially responsibl­e for his dementia, and there is a significan­t likelihood that he will do himself severe damage with continued use. Getting off this drug is difficult, and a consultati­on with an addiction specialist would serve him best. In the meantime, his doctor needs to re-evaluate his medical regimen to reduce risk of serotonin syndrome.

DEAR DR. ROACH: I’m 61 and had chickenpox as a young child. I also had shingles around age 12, which consisted of a row of blisters following along one of my ribs, from the front to the back, all along my side. This was diagnosed by my family doctor at the time. Should I get the shingles vaccine? Am I more prone to getting it as an older adult? My current family doctor had no opinion. -- A.M.

ANSWER: You are still at risk for shingles even if you had them in the past. I recommend the new two-dose shingles vaccine, Shingrix, for people over 50 with or without a history of chickenpox or shingles.

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