Patriots (2-4) at Bills (5-2)

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■ Time: 10 a.m.

■ Line/total: Bills -4, 40

■ Analysis: They say all good things must come to an end, and it seems as if New England’s dominant run in the AFC East is winding down after almost two decades as the Bills are leading the division. The Patriots lost their third straight game in last week’s 33-6 blowout loss to the 49ers. Buffalo eked out an 18-10 victory over the lowly Jets, kicking six field goals. Bills QB Josh Allen will have to find the end zone early and often for Buffalo to win this game.

■ By the numbers: The Patriots are 7-0 straight up and 5-2 ATS in their last seven meetings against Buffalo, but they’re on a 2-4 spread skid on the road. … The Bills are on a 3-7 spread slide. … Buffalo is on a 5-2 under run at home.

■ Pick: Patriots 23, Bills 20

Titans (5-1) at Bengals (1-5-1)

■ Time: 10 a.m.

■ Line/total: Titans -7, 50 ½

■ Analysis: Tennessee lost its first game in last week’s 27-24 defeat to the 6-0 Steelers. Next up for the Titans is another AFC North foe in the Bengals, who suffered a 37-34 loss to Cleveland in the final seconds. I expect both quarterbacks to throw for a lot of yards and points. Cincinnati rookie Joe Burrow threw for 406 yards against the Browns, and Tennessee QB Ryan Tannehill has thrown for 15 TDs and two interceptions.

■ By the numbers: The Titans are on a 2-5 ATS slide overall, but they’ve won seven of their last eight road games. … The Bengals are on a 4-1 ATS surge and have gone over in four of their last five games. … Cincinnati is 3-16-1 straight up in its last 20 games.

Titans 38, Bengals 31