Chargers (2-4) at Broncos (2-4)

■ Time: 1:05 p.m., KLAS-8

■ Line/total: Chargers -3 ½½ , 44

■ Analysis: The teams at the bottom of the AFC West face off in frosty Denver, where the Broncos got crushed 43-16 last week by Kansas City despite holding the Chiefs’ potent offense to 286 yards. Chargers QB Justin Herbert finally picked up his first victory as a starter in last week’s 39-29 home win over Jacksonville, throwing for 347 yards and three TDs. Denver has played the Chargers well over the years, winning 14 of the past 18 meetings overall and six of the last seven at home.

■ By the numbers: The Broncos are riding a 5-13 under streak at home. … Los Angeles is on a 4-1 cover run, but has lost nine of its last 12 games vs. AFC opponents.

■ Pick: Broncos 24, Chargers 20

Saints (4-2) at Bears (5-2)

■ Time: 1:25 p.m.

■ Line/total: Saints -5, 42

■ Analysis: The Bears continued to struggle offensively in Monday’s 24-10 loss to the Rams, scoring a field goal and defensive TD. Now they host Drew Brees and a New Orleans squad that notched its third straight win in last week’s 27-24 victory over Carolina. New Orleans has scored at least 20 points in 14 consecutive games and should continue that streak against a Bears defense that has been inconsistent.

■ By the numbers: The Saints have won the last five meetings against Chicago, going 4-1 ATS. … New Orleans is on a 15-5 straight-up run overall but is 1-4 ATS in its last five outings. … The Bears are on a 6-13 ATS slide. … Chicago is on a 7-1 under uptick at home.

■ Pick: Saints 26, Bears 19

49ers (4-3) at Seahawks (5-1)

■ Time: 1:25 p.m., KVVU-5

■ Line/total: Seahawks -3, 53 ½

■ Analysis: The Seahawks will look to get back into the win column against division foe San Francisco after suffering their first defeat in last week’s 37-34 loss at Arizona. Seattle QB Russell Wilson continues to cook with this offense, throwing for a league-leading 22 TDs (and six interceptions). The Niners picked up a 33-6 win at New England despite missing many key players because of injury. They will look to reverse the trend of losing to Seattle, which has won 11 of the last 13 meetings.

■ By the numbers: The Seahawks are riding a 14-4 cover streak against San Francisco, but they’re on a 5-9 ATS skid at home. … The Niners are 10-2 ATS in their last 12 road games. … San Francisco is on a 7-13 under streak in November.

■ Pick: Seahawks 31, Niners 24

Cowboys (2-5) at Eagles (2-4-1)

■ Time: 5:20 p.m., KSNV-3

■ Line/total: Eagles -10 ½½ , 42

■ Analysis: This battle in the “NFC Least” is not exactly mustsee TV during its prime-time slot, especially with Dallas down another quarterback after Andy Dalton suffered a concussion in last week’s 25-3 loss at Washington. The Cowboys and rookie QB Ben DiNucci take on an Eagles team that has had extra time to prepare after their 22-21 comeback victory over the Giants on “Thursday Night Football.”

■ By the numbers: Dallas is 0-7 ATS this season, but the Cowboys are riding a 15-5 ATS streak vs. NFC East foes. … The Eagles are 4-9 ATS in their past 13 games overall and 2-6 ATS in their last eight home games against the NFC East.

■ Pick: Eagles 24, Cowboys 17

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