Bills (7-2) at Cardinals (5-3) 49ers (4-5) at Saints (6-2) Bengals (2-5) at Steelers (8-0)

Time: 1:05 p.m.

Line/total: Cardinals -2 ½ , 56

Analysis: This game figures to be close, as both teams have struggled to win by margin against the better teams on their schedule. Arizona has allowed 34 points each to

Seahawks (6-2) at Rams (5-3)

■ Time: 1:25 p.m., KVVU-5

■ Line/total: Rams -2 ; 54

■ Analysis: The Rams’ offense is predicated on the running game and ability to play-action pass. They lead the league in pass attempts off play-action and are second in passing yards in play-action. Seattle’s defense has been horrible but has defended the run well, which could slow the Rams’ ability for play-action. On the flip side, the Rams are wellequipped to defend Seattle’s high-octane pass offense.

■ By the numbers: Seattle is on a 7-1 ATS run as a road underdog. The Seahawks went 6-2 straight up in those games, with the losses last season to the Rams, 36-31 and 28-12. … Los Angeles has won four of the last five meetings. … The Rams are on a 5-0 under run.

■ Pick: Rams 28, Seahawks 24

■ Time: 1:25 p.m.

■ Line/total: Saints -9 ; 49

■ Analysis: San Francisco remains banged up, missing its best players on both sides of the ball. New Orleans is coming off its biggest win of the season in a 38-3 rout at Tampa Bay. The Saints will have to avoid the typical letdown following such a big win.

■ By the numbers: New Orleans is on a 5-13 ATS slide as a home favorite of more than seven points. … The Niners are riding a 6-1 cover streak as road underdogs and are on a 9-3 ATS run on the road overall. … The over is 7-1 Saints games this season.

■ Pick: Saints 29, 49ers 23

■ Time: 1:25 p.m.

■ Line/total: Steelers -7 ; 46

■ Analysis: There are 20 mph winds expected in Pittsburgh. Cincinnati is below average throwing the ball, running the ball, defending the pass and defending the run (144 rushing yards per game allowed). The Steelers rank in the NFL’s top 10 in quarterback pressures allowed on Ben Roethlisberger, and the Bengals are second-worst in getting pressure on the QB. Roethlisberger should have time to throw, and Pittsburgh should be able to run on a bad Cincinnati rush defense.

■ By the numbers: The Bengals are on a 12-6 ATS uptick as road underdogs. … Pittsburgh has scored 24 points or more as favorites in 22 of its last 25 games that Roethlisberger has started. … The Steelers are riding an 18-9-1 over run with Roethlisberger at quarterback. … The under is 6-1-1 in the last eight meetings.

■ Pick: Steelers 27, Bengals 20

Ravens (6-2) at Patriots (3-5)

■ Time: 5:20 p.m., KSNV-3

■ Line/total: Ravens -7; 43

■ Analysis: New England was blown out 37-20 at Baltimore last season on “Sunday Night Football.” The loss started a 7-10 slide by the Patriots, who enter the rematch with a below-average offense and defense.

■ By the numbers: Ravens QB Lamar Jackson is 9-0 straight up and 6-1-2 ATS as a road favorite, winning seven of those games by seven points or more. Baltimore scored at least 30 points in seven of those games and allowed 17 or fewer in seven of them. Also, eight of those games totaled at least 46 points. … The Patriots are 1-2 as underdogs this season after going 13-3 ATS in their previous 16 games in that role.

■ Pick: Ravens 27, Patriots 17

Vikings (3-5) at Bears (5-4)

■ Time: 5:15 p.m. Monday, ESPN

■ Line/total: Vikings -3; 43

■ Analysis: These teams have headed in opposite directions the last few weeks, and the market has reflected that. The Vikings have won three of their past five games after an 0-3 start and look like the team we’ve seen the last few years. Chicago has lost three straight after a 5-1 start, and its offense is nowhere to be found.

■ By the numbers: Minnesota has struggled at Chicago going back to 2001. The Vikings are 3-16 straight up in their last 19 trips to Soldier Field and 4-14-1 ATS. … The Bears are riding a 13-4-1 ATS streak as home underdogs. … Minnesota fits a trend in which Monday night road teams coming off a double-digit home win and facing a team with a winning percentage of .334 or better are on a 12-32 spread slide.

■ Pick: Vikings 24, Bears 21