Panthers (4-7) at Vikings (4-6)

■ Time:

■ Line/total:

■ Analysis:

By the numbers:

■ Pick:

■ Time: 10 a.m.

■ Line/total: Vikings -3, 49

■ Analysis: It’s been tough for Carolina with star running back Christian McCaffrey playing in only three games. He’s been ruled out of this game, too, but there is a bright spot with the expected return of QB Teddy Bridgewater. The Panthers probably will lean on Mike Davis, who leads all running backs in receptions with 49. The Panthers are coming off a 20-0 shutout of Detroit, and their defense will do just enough to allow Bridgewater to pull this one out in the fourth quarter.

■ By the numbers: The Panthers are on a 6-1 cover streak as underdogs. … The underdog has covered five of the last six meetings.

■ Pick: Panthers 26, Vikings 23

Titans (7-3) at Colts (7-3)

■ Time: 10 a.m.

■ Line/total: Colts -3, 51 ½

■ Analysis: I’ve seen this scenario before, where a team’s depleted defensive line (Colts) faces the league’s leading rusher (Derrick Henry). This appears to be a chance for Henry to have a huge day, but sports betting is rarely that easy. We don’t give enough credit to backups, and Indianapolis’ reserves will get the chance to prove their worth for the NFL’s No. 2 total defense. We also can’t overlook Frank Reich’s stellar coaching staff. Henry will get his yards, but the Colts’ defense will come up big again.

■ By the numbers: Indy is 14-5 ATS vs. teams with a winning record and 8-3 ATS vs. the AFC South. … The favorite is 13-3 ATS in the last 16 meetings. … The under is 14-5 in the last 19 meetings in Indianapolis.

■ Pick: Colts 28, Titans 21 21 road games and 32-15-4 ATS in their past 51 games as road underdogs. … Los Angeles has covered the last four meetings. … The Chargers are on a 39-19-1 under streak after a win.

Pick: Bills 27, Chargers 24