■ Two GOP senators said they would vote against confirming a Cabinet nominee.

WASHINGTON — President Joe Biden’s nomination of Neera Tanden to lead the White House Office of Management and Budget was thrown further into doubt on Monday as moderate Republican Sens. Susan Collins of Maine and Mitt Romney of Utah said they would vote against confirming her.

On Friday, Sen. Joe Manchin of West Virginia became the first Democratic lawmaker to oppose the confirmation of Tanden. With doubts growing about Tanden’s chances for confirmation, the White House called her “an accomplished policy expert,” and Biden said he was sticking with her.

Collins, though, said Monday that Tanden has “neither the experience nor the temperament to lead this critical agency,” which heads efforts to ensure an administration’s priorities are reflected in legislation and regulations. Collins blamed Tanden’s past actions and said they “demonstrated exactly the kind of animosity that President Biden has pledged to transcend.”

Romney will also oppose Tanden, a spokesperson confirmed, because of her rhetoric on social media.

The Senate Budget Committee is scheduled to vote on Tanden’s nomination this week.