Lodi News-Sentinel

Part-monkey, part-human embryo raises questions about ethics

- SUZY COHEN DEAR PHARMACIST

An experiment has taken place where researcher­s just created an embryo that is half-human and half-monkey. They allowed the living thing to grow for 20 days, and then it was destroyed.

This experiment has sparked huge debate into the ethical reasons for such an experiment, and whether they should be allowed to continue. And if so, where exactly should the research end?

The lead researcher, Professor Juan Carlos Izpisua Belmonte, has experience in the field of biomedical research. In 2017, he helped create the first human-pig embryo, which lived for a month.

Professor Belmonte teamed up with researcher­s in China more recently, and injected human cells into monkey embryos instead of sheep, because the latter does not work well. But a monkey’s genomic sequence is closer to that of humans, and in the end, the experiment worked. A monkey-human hybrid was made, and lived for 20 days and was then destroyed.

Dr. Belmonte’s team proposes that a major problem in medicine can possibly be solved, and he’s referring to organ transplant­ation. Every 2 or 3 weeks, someone passes away because they did not get the organ they so desperatel­y needed. This type of stem cell research — the ability to grow a kidney or a liver, for example — would solve the shortage we have, and save many lives each year.

Will future embryos remain in the petri dish, or will an unethical scientist secretly create one and attempt to propagate a new kind of creature? There are so many obvious bioethical concerns with this.

Then there’s the issue of disease transmissi­on. There are “mad cow” disease, Bartonella infection (from a cat’s scratch), and most recently, bats transmitti­ng coronaviru­s. Monkeys famously carry herpes B virus, monkeypox and rabies. When genetic material from a monkey is sourced for this purpose, it is exceedingl­y difficult, if not impossible, to be 100% assured that it does not contain anything dangerous to a human.

Other scientists are raising concerns about where it should stop. The argument is that in time, as “chimeric” technology improves, an unethical scientist could after hours go ahead and implant an embryo into a monkey, and ethically would would happen to that baby? It may conjure up ideas in some people’s minds about more Frankenste­inish experiment­s, as well as partanimal, part-human offspring.

Human chimeras already exist. In fact, research shows that people who have received bone marrow transplant­s or women who have had a pregnancy all have chimeric cells in them. What we’re talking about today is different. It is a scientific experiment­al chimera that is neither animal nor human.

The world is not united on the new research. Some people see it as a positive, a new opportunit­y to create organs for transplant­ations that could save human lives every day. Other people see this as a negative. They perceive it as opening Pandora’s box to a 21st century “Planet of the Apes,” and question where the researcher­s would stop if they are given an inch.

How many lives would be saved exactly?

If you have an opinion about this, email me at scriptesse­ntials@gmail.co m. This informatio­n is not intended to diagnose, treat, cure or prevent any disease. For a longer version of this article, visit Suzy Cohen’s website at www.suzycohen.com.

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