Los Angeles Times

Same drug, wild cost difference

- DAVID LAZARUS

As sky-high EpiPen costs show, price gouging of patients by greedy drug companies is one part of our dysfunctio­nal healthcare system. Another is what may appear to be the arbitrary way that insurers decide what co-pay to charge.

Santa Ana residents William and Phyllis Stevens encountere­d this recently when they were both prescribed the same cream for pre-cancerous skin growths.

One had a co-pay of $20, the other a co-insurance cost of $300. And the muchhigher charge was levied for a version of the medicine that was weaker than the cheaper version — yet had jumped nearly 1,500% in price since 2009. Welcome to Crazy Town. “There’s no good economic rationale for why this happens,” said Gerald Kominski, director of the UCLA Center for Health Policy Research. “But it happens all the time.”

Insurers’ decisions about which drugs will be placed on which pricing tier can have a significan­t effect on patients.

Tier 1 and Tier 2 drugs typically will be generic or commonly prescribed medication­s and will have lower co-pays. Drugs on higher tiers will be regarded by the insurer as “specialty” meds and will come with higher co-pays or co-insurance costs.

Co-insurance is a percentage of the drug’s cost, usually about 25%, rather than a fixed co-payment.

“What this illustrate­s is that there are things we don’t think about when we buy insurance,” Kominski said. “But when we use insurance, we’re in for surprises.”

He said it’s a system “that requires us to be more and more sophistica­ted. But no one’s that smart.”

Shana Alex Charles, an assistant professor of health sciences at Cal State Fullerton, put it like this: “Much of our insurance system flies in the face of reason.”

The Stevens’ experience comes amid the ongoing fracas over pharmaceut­ical heavyweigh­t Mylan boosting the price of EpiPens by more than 400% — the latest example of a drug company seeking sky-high payments for a medication that’s been around for decades.

Families have long relied on EpiPens to administer epinephrin­e, a hormone that counters the potentiall­y fatal effects of severe allergic reactions to things such as bee stings and peanuts. There’s about a dollar’s worth of epinephrin­e in each EpiPen, to which Mylan purchased the rights in 2007 and proceeded to impose a string of double-digit price hikes.

On Monday, Mylan announced that it will introduce a generic version of the EpiPen for half the cost. But that still will mean $300 for a pack of two and potentiall­y will give Mylan even more control over the market by discouragi­ng other generic manufactur­ers from trying to compete.

William Stevens, 83, told me he and his wife were both prescribed generic fluorourci­l after their dermatolog­ist found pre-cancerous growths on their skin. They were each given a prescripti­on for a topical cream containing 5% of the drug.

The couple is insured by Scan Health Plan of Long Beach, which provides supplement­al Medicare Advantage coverage to seniors. It’s a not-for-profit organizati­on founded in 1977.

Stevens’ 81-year-old wife filled her prescripti­on first. Because 5% fluorourci­l was a Tier 3 drug for Scan, she was charged a $20 co-pay.

A few weeks later, Stevens filled his own prescripti­on. This time, the pharmacist said she was out of 5% fluorourci­l but could give the 0.5% strength. However, the pharmacist warned, this was a Tier 5 drug for Scan and thus would come with a co-insurance payment of $300.

Think about that: the same exact drug at a tenth of the strength costing more than 10 times as much.

“I asked the pharmacist how that could be,” Stevens recalled. “She had no explanatio­n.”

There’s an explanatio­n, but it’s not a very satisfying one.

Insurers use tiered pricing to steer members to the most affordable options, usually generics. In the case of fluorourci­l, the 5% formulatio­n is generic, so that’s the one Scan placed in its cheaper Tier 3.

The 0.5% version contains the same active ingredient but isn’t generic — it’s sold under the brand name Carac. So the insurer bumped it to Tier 5.

“It’s a loony situation,” acknowledg­ed Sharon Jhawar, Scan’s vice president of pharmacy. “It’s maddening even to us.”

Loonier still, the manufactur­er of Carac, Valeant Pharmaceut­icals, has indulged in price hikes that make Mylan’s greed seem miserly by comparison. Valeant has drawn fire in the past for jacking up drug prices to astronomic levels, including a more than 700% increase in the price of heart medicine Isuprel.

In 2009, Jhawar said, a 30-gram tube of Carac sold for $160. It now runs closer to $2,500 — and that’s the discounted price negotiated by most insurers, she said. Valeant’s desired price is even higher.

Remember: same active ingredient as the generic, only less.

I asked Valeant why the price of Carac has risen nearly 1,500% since 2009. The company sent me a statement that didn’t address that question.

Instead, it said Valeant, which replaced its chief executive in March, has set up a committee that “will take a discipline­d approach to reviewing the company's pricing of drugs, and will consider the impact on patients, doctors and our healthcare industry partners.”

“While we will raise prices from time to time, we expect those price increases to be much more modest and within industry norms,” it said. “With respect to Carac, a lower-priced generic alternativ­e is available.”

Well, that’s good news. Or maybe not.

Jhawar said Valeant gave permission last year for another drug maker, Spear Pharmaceut­icals, to sell an “authorized generic” version of Carac until Valeant’s patent expires in 2021.

The price of that authorized generic? A mere $1,300 a tube.

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 ?? Ryan Remiorz Associated­Press ?? VALEANT makes the brand name drug Carac, which costs several times more than generic f luorourcil despite having just one-tenth the active ingredient.
Ryan Remiorz Associated­Press VALEANT makes the brand name drug Carac, which costs several times more than generic f luorourcil despite having just one-tenth the active ingredient.

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