Saints ....................... 47 Bills ........................... 10
Mark Ingram scored a career-best three touchdowns and New Orleans blew the game open by scoring five times on its first six possessions, not including a one-play series to close the first half, on the way to its seventh consecutive victory.
Ingram finished with 131 yards rushing. The Saints finished with 298 yards rushing and 32 first downs, and set a franchise record by scoring six touchdowns rushing, the most given up by Buffalo all-time.
The Saints never punted, and the only thing to stop them was tight end Josh Hill losing a fumble at the Buffalo nine in the first quarter.